G D Bren
Overview
Explore the profile of G D Bren including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
398
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Recent Articles
1.
Vlahakis S, Bren G, Algeciras-Schimnich A, Trushin S, Schnepple D, Badley A
Clin Pharmacol Ther
. 2007 Mar;
82(3):294-9.
PMID: 17361127
Human immunodeficiency virus (HIV) infection results in excessive apoptosis of infected and uninfected cells, mediated by host and viral factors present in plasma. As HIV protease inhibitors (PIs) have intrinsic...
2.
Bren G, Solan N, Miyoshi H, Pennington K, Pobst L, Paya C
Oncogene
. 2001 Dec;
20(53):7722-33.
PMID: 11753650
RelA and RelB are two members of the NF-kappaB family that differ structurally and functionally. While RelA is regulated through its cytosolic localization by inhibitor proteins or IkappaB and not...
3.
Asin S, Bren G, Carmona E, Solan N, Paya C
J Virol
. 2001 Nov;
75(23):11408-16.
PMID: 11689622
The role of NF-kappaB in the reactivation of human immunodeficiency virus (HIV) from latency in CD4 T lymphocytes is well documented. However, its role in driving HIV transcription in human...
4.
Pennington K, Taylor J, Bren G, Paya C
Mol Cell Biol
. 2001 Mar;
21(6):1930-41.
PMID: 11238929
The molecular mechanisms regulating monocyte differentiation to macrophages remain unknown. Although the transcription factor NF-kappaB participates in multiple cell functions, its role in cell differentiation is ill defined. Since differentiated...
5.
Bren G, Pennington K, Paya C
J Mol Biol
. 2000 Apr;
297(5):1245-58.
PMID: 10764587
The atypical PKC isoenzymes, zeta and iota, activate NF-kappaB, a mechanism thought to mediate the anti-apoptotic and proliferative features of these kinases. PKC-zeta has been shown to be associated with...
6.
Ten R, McKinstry M, Bren G, Paya C
J Allergy Clin Immunol
. 1999 Aug;
104(2 Pt 1):376-87.
PMID: 10452760
Background: Alveolar macrophages play a key role in the initiation of the inflammatory reaction of allergic asthma. Alveolar macrophages and peripheral blood monocytes are activated when IgE/allergen immune complexes bind...
7.
Taylor J, Bren G, Pennington K, Trushin S, Asin S, Paya C
J Mol Biol
. 1999 Jul;
290(4):839-50.
PMID: 10398585
IkappaBalpha is an inherently unstable protein which binds to and retains the ubiquitous transcription factor NFkappaB in the cytoplasm of resting cells. A continuous low level translocation of NFkappaB to...
8.
Folgueira L, Algeciras A, MacMorran W, Bren G, Paya C
J Virol
. 1996 Apr;
70(4):2332-8.
PMID: 8642660
Persistent human immunodeficiency virus (HIV) infection of human monocytes and macrophages increases I kappa B alpha degradation, resulting in the activation of NF-kappa B, a key transcription factor in the...
9.
McElhinny J, Trushin S, Bren G, Chester N, Paya C
Mol Cell Biol
. 1996 Mar;
16(3):899-906.
PMID: 8622692
The phosphoprotein I kappa B alpha exists in the cytoplasm of resting cells bound to the ubiquitous transcription factor NF-kappa B (p50-p65). In response to specific cellular stimulation, I kappa...
10.
Folgueira L, McElhinny J, Bren G, MacMorran W, Diaz-Meco M, Moscat J, et al.
J Virol
. 1996 Jan;
70(1):223-31.
PMID: 8523529
The molecular mechanisms regulating human immunodeficiency virus (HIV) persistence in a major cell reservoir such as the macrophage remain unknown. NF-kappa B is a transcription factor involved in the regulation...