G Beskid
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Explore the profile of G Beskid including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
145
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Recent Articles
1.
Prosser B, Beskid G
Diagn Microbiol Infect Dis
. 1995 Jan;
21(1):33-45.
PMID: 7789095
In vitro activities of fleroxacin, ciprofloxacin, ofloxacin, and lomefloxacin were evaluated against 25,129 fresh bacterial isolates from 51 US hospital or medical center laboratories, beginning in October of 1990. Susceptibility...
2.
Albrecht H, Beskid G, Christenson J, Deitcher K, Georgopapadakou N, Keith D, et al.
J Med Chem
. 1994 Feb;
37(3):400-7.
PMID: 8308866
We have previously reported that linking quinolones to the cephalosporin 3'-position through an ester bond, a carbamate function, or a bond through a quaternary nitrogen produced cephalosporins with a dual...
3.
Beskid G, Prosser B
Am J Med
. 1993 Mar;
94(3A):2S-8S.
PMID: 8383919
A multicenter study was designed to compare the in vitro activity of fleroxacin to that of three other oral quinolones (ciprofloxacin, ofloxacin, and lomefloxacin) against fresh clinical bacterial isolates in...
4.
Albrecht H, Beskid G, Christenson J, Georgopapadakou N, Keith D, Konzelmann F, et al.
J Med Chem
. 1991 Sep;
34(9):2857-64.
PMID: 1910090
A series of cephalosporins has been prepared in which the 3'-position was linked to the nitrogen of the antibacterial quinolone ciprofloxacin through a carbamate function. Like the ester-linked and quaternary-linked...
5.
Albrecht H, Beskid G, Christenson J, Durkin J, Fallat V, Georgopapadakou N, et al.
J Med Chem
. 1991 Feb;
34(2):669-75.
PMID: 1847430
When cephalosporins exert their biological activity by reacting with bacterial enzymes, opening of the beta-lactam ring can lead to expulsion of the 3'-substituent. A series of cephalosporins was prepared in...
6.
Beskid G, Albrecht H, Fallat V, Keith D, Lipschitz E, McGarry C, et al.
Chemotherapy
. 1991 Jan;
37(5):310-7.
PMID: 1804592
Ro 24-4383 contains desacetylcefotaxime linked by a carbamate bond at the 3' position to ciprofloxacin. Ro 24-4383 was active against 99% of the 363 gram-positive and gram-negative aerobes tested in...
7.
Albrecht H, Beskid G, Chan K, Christenson J, Cleeland R, Deitcher K, et al.
J Med Chem
. 1990 Jan;
33(1):77-86.
PMID: 2153215
According to the generally accepted mechanism by which bacterial enzymes react with cephalosporins, opening of the beta-lactam ring can lead to the expulsion of a 3'-substituent. A series of dual-action...
8.
In vivo evaluation of a dual-action antibacterial, Ro 23-9424, compared to cefotaxime and fleroxacin
Beskid G, Siebelist J, McGarry C, Cleeland R, Chan K, Keith D
Chemotherapy
. 1990 Jan;
36(2):109-16.
PMID: 2107064
The dual-action antibacterial R 23-9424 (desacetylcefotaxime linked to the quinolone fleroxacin) is a new antibacterial agent with excellent in vitro activity. It was evaluated for in vivo efficacy in comparison...
9.
Beskid G, Fallat V, Lipschitz E, McGarry D, Cleeland R, Chan K, et al.
Antimicrob Agents Chemother
. 1989 Jul;
33(7):1072-7.
PMID: 2782857
The in vitro activity of the dual-action antibacterial agent Ro 23-9424 was compared with those of cefotaxime, ceftazidime, ciprofloxacin, fleroxacin, imipenem, and amikacin against 358 aerobes and anaerobes. The MIC...
10.
Beskid G, Unowsky J, Behl C, Siebelist J, Tossounian J, McGarry C, et al.
Chemotherapy
. 1988 Jan;
34(2):77-84.
PMID: 3391054
In vivo models in rodents and primates were used to investigate ways of overcoming the poor oral and rectal absorption of ceftriaxone. The sodium salt of ceftriaxone at 20 mg/kg...