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G A Wiggan

Explore the profile of G A Wiggan including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 32
Followers 0
Related Specialties
Allergy & Immunology
Pharmacology
Biochemistry
Top 10 Co-Authors
A M Gilfillan
A F Welton
J P Kochan
G Bandara
P Y Lin
B Repetto
M Basu
J D Larigan
W C Hope
J Hakimi
Published In
J Immunol
Biochem Pharmacol
Eur J Pharmacol
Biochim Biophys Acta
Agents Actions
Affiliations
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Recent Articles
1.
Functional contributions of the FcepsilonRIalpha and FepsilonRIgamma subunit domains in FcepsilonRI-mediated signaling in mast cells
Repetto B, Bandara G, Larigan J, Wiggan G, Pocius D, Basu M, et al.
J Immunol . 1996 Jun; 156(12):4876-83. PMID: 8648137
The functional contributions of the alpha and gamma subunit domains of the high affinity receptor for IgE (Fcepsilon-RI) were determined following chimeric receptor aggregation. Chimeric receptors of the extracellular (EC)...
2.
Functional characterization of the signal transduction events mediated by Fc epsilon RI alpha and gamma chimeric receptors
Repetto B, Bandara G, Wiggan G, Gilfillan A, Kochan J
Int Arch Allergy Immunol . 1995 May; 107(1-3):66-8. PMID: 7542105
Chimeric receptors containing the Fc epsilon RI alpha and gamma subunit domains were constructed, stably transfected into RBL-2H3 cells, and characterized for the biochemical events which are elicited upon receptor...
3.
Conservation of signal transduction mechanisms via the human Fc epsilon RI alpha after transfection into a rat mast cell line, RBL 2H3
Gilfillan A, Wiggan G, Hakimi J, Kent U, Kochan J
J Immunol . 1992 Oct; 149(7):2445-51. PMID: 1382104
The high affinity receptor for IgE (Fc epsilon RI) is present on mast cells and basophils, and the aggregation of IgE-occupied receptors by Ag is responsible for the release of...
4.
Differential effects of propranolol on the IgE-dependent, or calcium ionophore-stimulated, phosphoinositide hydrolysis and calcium mobilization in a mast (RBL 2H3) cell line
Lin P, Wiggan G, Welton A, Gilfillan A
Biochem Pharmacol . 1991 Jun; 41(12):1941-8. PMID: 1710122
Our previous studies demonstrated that propranolol, an inhibitor of phosphatidic acid phosphohydrolase (PAPase) (EC 3.1.3.4) blocks the IgE-dependent mediator release from a rat mast (RBL 2H3) cell line. To continue...
5.
Activation of phospholipase D in a rat mast (RBL 2H3) cell line. A possible unifying mechanism for IgE-dependent degranulation and arachidonic acid metabolite release
Lin P, Wiggan G, Gilfillan A
J Immunol . 1991 Mar; 146(5):1609-16. PMID: 1704399
RBL 2H3 cells (a model of mast cell function) were sensitized with anti-TNP IgE (0.5 micrograms/ml) and triggered to secrete both histamine and arachidonic acid (AA) metabolites by the addition...
6.
The effects of the protein kinase C inhibitors staurosporine and H7 on the IgE dependent mediator release from RBL 2H3 cells
Gilfillan A, Wiggan G, Welton A
Agents Actions . 1990 Jun; 30(3-4):418-25. PMID: 1696778
RBL 2H3 cells, a model for mast cell function, sensitized with rat IgE, released histamine and peptidoleukotrienes (LT) in response to rabbit anti-rat IgE in a concentration-dependent manner. The calcium...
7.
Pertussis toxin pretreatment reveals differential effects of adenosine analogs on IgE-dependent histamine and peptidoleukotriene release from RBL-2H3 cells
Gilfillan A, Wiggan G, Welton A
Biochim Biophys Acta . 1990 May; 1052(3):467-74. PMID: 2162218
The effects of adenosine (A) and the nonmetabolizable adenosine analogs, N-ethylcarboxamidoadenosine (NECA), L-phenylisopropyladenosine (L-PIA), D-PIA and 2-chloroadenosine (2CHA) were examined on the IgE-dependent mediator release from RBL-2H3 cells, a model...
8.
Ro 19-3704 directly inhibits immunoglobulin E-dependent mediator release by a mechanism independent of its platelet-activating factor antagonist properties
Gilfillan A, Wiggan G, Hope W, Patel B, Welton A
Eur J Pharmacol . 1990 Feb; 176(3):255-62. PMID: 1691711
Rat basophilic leukemia (RBL 2H3) cells were passively sensitized by exposure to monoclonal anti-trinitrophenol mouse immunoglobulin E (anti-trinitrophenol IgE) (0.5 microgram/ml) and triggered by exposure to a sub-optimal concentration of...