Frederik Roels
Overview
Explore the profile of Frederik Roels including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
1480
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Recent Articles
1.
Dorneburg C, Goss A, Fischer M, Roels F, Barth T, Berthold F, et al.
Oncotarget
. 2016 Sep;
7(39):62799-62813.
PMID: 27588497
As high-risk neuroblastoma (NB) has a poor prognosis, new therapeutic modalities are needed. We therefore investigated the susceptibility of NB cells to γ-secretase inhibitor I (GSI-I). NOTCH signaling activity, the...
2.
Brockmann M, Poon E, Berry T, Carstensen A, Deubzer H, Rycak L, et al.
Cancer Cell
. 2016 Aug;
30(2):357-358.
PMID: 27505677
No abstract available.
3.
Powers J, Tsanov K, Pearson D, Roels F, Spina C, Ebright R, et al.
Nature
. 2016 Jul;
535(7611):246-51.
PMID: 27383785
Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN. MYCN is itself a target of let-7, a tumour suppressor family of microRNAs implicated in numerous cancers. LIN28B, an...
4.
Bae-Gartz I, Janoschek R, Kloppe C, Vohlen C, Roels F, Oberthur A, et al.
Med Sci Sports Exerc
. 2015 Dec;
48(5):829-38.
PMID: 26694850
Purpose: Maternal obesity is known to predispose the offspring to impaired glucose metabolism and obesity associated with low-grade inflammation and hypothalamic dysfunction. Because preventive approaches in this context are missing...
5.
Ikram F, Ackermann S, Kahlert Y, Volland R, Roels F, Engesser A, et al.
Mol Oncol
. 2015 Nov;
10(2):344-59.
PMID: 26598443
Neuroblastoma is an embryonal pediatric tumor that originates from the developing sympathetic nervous system and shows a broad range of clinical behavior, ranging from fatal progression to differentiation into benign...
6.
Peifer M, Hertwig F, Roels F, Dreidax D, Gartlgruber M, Menon R, et al.
Nature
. 2015 Oct;
526(7575):700-4.
PMID: 26466568
Neuroblastoma is a malignant paediatric tumour of the sympathetic nervous system. Roughly half of these tumours regress spontaneously or are cured by limited therapy. By contrast, high-risk neuroblastomas have an...
7.
Schramm A, Koster J, Assenov Y, Althoff K, Peifer M, Mahlow E, et al.
Nat Genet
. 2015 Jun;
47(8):872-7.
PMID: 26121086
Neuroblastoma is a malignancy of the developing sympathetic nervous system that is often lethal when relapse occurs. We here used whole-exome sequencing, mRNA expression profiling, array CGH and DNA methylation...
8.
Zhang W, Yu Y, Hertwig F, Thierry-Mieg J, Zhang W, Thierry-Mieg D, et al.
Genome Biol
. 2015 Jun;
16:133.
PMID: 26109056
Background: Gene expression profiling is being widely applied in cancer research to identify biomarkers for clinical endpoint prediction. Since RNA-seq provides a powerful tool for transcriptome-based applications beyond the limitations...
9.
Ackermann S, Kocak H, Hero B, Ehemann V, Kahlert Y, Oberthuer A, et al.
BMC Cancer
. 2014 Nov;
14:840.
PMID: 25406647
Background: Segmental genomic copy number alterations, such as loss of 11q or 3p and gain of 17q, are well established markers of poor outcome in neuroblastoma, and have been suggested...
10.
Walz S, Lorenzin F, Morton J, Wiese K, von Eyss B, Herold S, et al.
Nature
. 2014 Jul;
511(7510):483-7.
PMID: 25043018
In mammalian cells, the MYC oncoprotein binds to thousands of promoters. During mitogenic stimulation of primary lymphocytes, MYC promotes an increase in the expression of virtually all genes. In contrast,...