Freddy Van Goethem
Overview
Explore the profile of Freddy Van Goethem including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
18
Citations
232
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0
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Recent Articles
1.
Sepehri S, De Win D, Heymans A, Van Goethem F, Rodrigues R, Rogiers V, et al.
Regul Toxicol Pharmacol
. 2025 Mar;
159:105794.
PMID: 40024558
This study employs animal-free Next Generation Risk Assessment (NGRA) principles to evaluate the safety of repeated dermal exposure to 2.5% (w/w) HC Yellow No. 13 (HCY13) hair dye. As multiple...
2.
Rao M, Nassiri V, Alhambra C, Snoeys J, Van Goethem F, Irrechukwu O, et al.
Chem Res Toxicol
. 2023 Jun;
36(7):1129-1139.
PMID: 37294641
Drug-induced liver injury (DILI), believed to be a multifactorial toxicity, has been a leading cause of attrition of small molecules during discovery, clinical development, and postmarketing. Identification of DILI risk...
3.
Pognan F, Beilmann M, Boonen H, Czich A, Dear G, Hewitt P, et al.
Nat Rev Drug Discov
. 2023 Feb;
22(4):317-335.
PMID: 36781957
For decades, preclinical toxicology was essentially a descriptive discipline in which treatment-related effects were carefully reported and used as a basis to calculate safety margins for drug candidates. In recent...
4.
Beilmann M, Boonen H, Czich A, Dear G, Hewitt P, Mow T, et al.
ALTEX
. 2018 Dec;
36(2):289-313.
PMID: 30570669
Investigative Toxicology describes the de-risking and mechanistic elucidation of toxicities, supporting early safety decisions in the pharmaceutical industry. Recently, Investigative Toxicology has contributed to a shift in pharmaceutical toxicology, from...
5.
Lovell D, Fellows M, Marchetti F, Christiansen J, Elhajouji A, Hashimoto K, et al.
Mutat Res Genet Toxicol Environ Mutagen
. 2018 Jan;
825:40-50.
PMID: 29307374
The recent revisions of the Organisation for Economic Co-operation and Development (OECD) genetic toxicology test guidelines emphasize the importance of historical negative controls both for data quality and interpretation. The...
6.
Verbist B, Verheyen G, Vervoort L, Crabbe M, Beerens D, Bosmans C, et al.
Chem Res Toxicol
. 2015 Aug;
28(10):1914-25.
PMID: 26313431
During drug discovery and development, the early identification of adverse effects is expected to reduce costly late-stage failures of candidate drugs. As risk/safety assessment takes place rather late during the...
7.
Mesens N, Crawford A, Menke A, Hung P, Van Goethem F, Nuyts R, et al.
J Appl Toxicol
. 2015 Feb;
35(9):1017-29.
PMID: 25663337
Drug-induced liver injury (DILI) is poorly predicted by single-cell-based assays, probably because of the lack of physiological interactions with other cells within the liver. An intact whole liver system such...
8.
Bryce S, Avlasevich S, Bemis J, Tate M, Walmsley R, Saad F, et al.
Environ Mol Mutagen
. 2013 Mar;
54(3):180-94.
PMID: 23447390
An automated approach for scoring in vitro micronuclei (MN) has been described in which flow cytometric analysis is combined with compound exposure, processing, and sampling in a single 96-well plate...
9.
Moore M, Honma M, Clements J, Awogi T, Douglas G, Van Goethem F, et al.
Mutat Res
. 2011 Apr;
723(2):84-6.
PMID: 21514400
The Mouse Lymphoma Expert Workgroup of the International Workshop for Genotoxicity Tests (IWGT) met in Basel, Switzerland in August of 2009. The Workgroup (WG) was tasked with discussing the appropriate...
10.
Avlasevich S, Bryce S, De Boeck M, Elhajouji A, Van Goethem F, Lynch A, et al.
Mutagenesis
. 2010 Dec;
26(1):147-52.
PMID: 21164196
The relative simplicity of the in vitro micronucleus (MNvit) endpoint has made it amenable to several automated scoring approaches. Flow cytometry is one such scoring platform that has been successfully...