Fraser R Cummings
Overview
Explore the profile of Fraser R Cummings including associated specialties, affiliations and a list of published articles.
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6
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1465
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Recent Articles
1.
Culver E, Bungay H, Betts M, Forde C, Buchel O, Manganis C, et al.
Liver Int
. 2020 Aug;
40(11):2744-2757.
PMID: 32841490
Background: Primary sclerosing cholangitis (PSC) is closely associated with inflammatory bowel disease, particularly ulcerative colitis (UC), with an increased risk of biliary and colorectal malignancy. We sought to clarify the...
2.
Walker G, Harrison J, Heap G, Voskuil M, Andersen V, Anderson C, et al.
JAMA
. 2019 Feb;
321(8):773-785.
PMID: 30806694
Importance: Use of thiopurines may be limited by myelosuppression. TPMT pharmacogenetic testing identifies only 25% of at-risk patients of European ancestry. Among patients of East Asian ancestry, NUDT15 variants are...
3.
Heap G, Weedon M, Bewshea C, Singh A, Chen M, Satchwell J, et al.
Nat Genet
. 2014 Sep;
46(10):1131-4.
PMID: 25217962
Pancreatitis occurs in approximately 4% of patients treated with the thiopurines azathioprine or mercaptopurine. Its development is unpredictable and almost always leads to drug withdrawal. We identified patients with inflammatory...
4.
Fisher S, Tremelling M, Anderson C, Gwilliam R, Bumpstead S, Prescott N, et al.
Nat Genet
. 2008 Apr;
40(6):710-2.
PMID: 18438406
We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to...
5.
Burton P, Clayton D, Cardon L, Craddock N, Deloukas P, Duncanson A, et al.
Nat Genet
. 2007 Oct;
39(11):1329-37.
PMID: 17952073
We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease (AITD), multiple sclerosis (MS)...
6.
Parkes M, Barrett J, Prescott N, Tremelling M, Anderson C, Fisher S, et al.
Nat Genet
. 2007 Jun;
39(7):830-2.
PMID: 17554261
A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and...