Frank R Sharp
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Explore the profile of Frank R Sharp including associated specialties, affiliations and a list of published articles.
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161
Citations
6359
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Recent Articles
1.
Knepp B, Navi B, Rodriguez F, DeAngelis L, Elkind M, Iadecola C, et al.
Ann Neurol
. 2024 Jun;
96(3):565-581.
PMID: 38874304
Objective: Approximately half of ischemic strokes (IS) in cancer patients are cryptogenic, with many presumed cardioembolic. We evaluated whether there were specific miRNA and mRNA transcriptome architectures in peripheral blood...
2.
Knepp B, Ander B, Jickling G, Hull H, Yee A, Ng K, et al.
Brain Hemorrhages
. 2023 Mar;
3(4):155-176.
PMID: 36936603
The peripheral immune system response to Intracerebral Hemorrhage (ICH) may differ with ICH in different brain locations. Thus, we investigated peripheral blood mRNA expression of Deep ICH, Lobar ICH, and...
3.
Sharp F, DeCarli C, Jin L, Zhan X
Front Aging Neurosci
. 2023 Feb;
15:1096206.
PMID: 36845656
We postulate that myelin injury contributes to cholesterol release from myelin and cholesterol dysmetabolism which contributes to Abeta dysmetabolism, and combined with genetic and AD risk factors, leads to increased...
4.
Carmona-Mora P, Knepp B, Jickling G, Zhan X, Hakoupian M, Hull H, et al.
BMC Med
. 2023 Feb;
21(1):65.
PMID: 36803375
Background: After ischemic stroke (IS), peripheral leukocytes infiltrate the damaged region and modulate the response to injury. Peripheral blood cells display distinctive gene expression signatures post-IS and these transcriptional programs...
5.
Early peripheral blood gene expression associated with good and poor 90-day ischemic stroke outcomes
Amini H, Knepp B, Rodriguez F, Jickling G, Hull H, Carmona-Mora P, et al.
J Neuroinflammation
. 2023 Jan;
20(1):13.
PMID: 36691064
Background: This study identified early immune gene responses in peripheral blood associated with 90-day ischemic stroke (IS) outcomes. Methods: Peripheral blood samples from the CLEAR trial IS patients at ≤ ...
6.
Puglisi C, Ander B, Peterson C, Keiter J, Hull H, Hawk C, et al.
Transl Stroke Res
. 2022 Jul;
14(4):572-588.
PMID: 35821378
The mechanisms of cognitive decline after intraventricular hemorrhage (IVH) in some patients continue to be poorly understood. Multiple rodent models of intraventricular or subarachnoid hemorrhage have only shown mild or...
7.
Jickling G, Ander B, Zhan X, Stamova B, Hull H, DeCarli C, et al.
Brain
. 2022 Mar;
145(9):3179-3186.
PMID: 35325079
Cerebral white matter hyperintensities are an important contributor to ageing brain pathology. Progression in white matter hyperintensity volume is associated with cognitive decline and gait impairment. Understanding the factors associated...
8.
Ibanez L, Heitsch L, Carrera C, Farias F, Del Aguila J, Dhar R, et al.
Brain
. 2022 Feb;
145(7):2394-2406.
PMID: 35213696
During the first hours after stroke onset, neurological deficits can be highly unstable: some patients rapidly improve, while others deteriorate. This early neurological instability has a major impact on long-term...
9.
Ye Z, Izadi A, Gurkoff G, Rickerl K, Sharp F, Ander B, et al.
J Neurotrauma
. 2022 Feb;
39(7-8):520-529.
PMID: 35109711
Our previous studies demonstrated that traumatic brain injury (TBI) and ventricular administration of thrombin caused hippocampal neuron loss and cognitive dysfunction via activation of Src family kinases (SFKs). Based on...
10.
Zhan X, Hakoupian M, Jin L, Sharp F
Front Aging Neurosci
. 2021 Dec;
13:705594.
PMID: 34899263
(CA) increase in number and size with aging. Their origins and functions remain unknown. Previously, we found that Alzheimer's disease (AD) brains have more in the periventricular white matter (PVWM)...