Frank Lehmann-Horn
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Explore the profile of Frank Lehmann-Horn including associated specialties, affiliations and a list of published articles.
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86
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1595
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Recent Articles
1.
Hoppe K, Sartorius T, Chaiklieng S, Wietzorrek G, Ruth P, Jurkat-Rott K, et al.
Front Physiol
. 2020 Dec;
11:533946.
PMID: 33329012
Reduced Cl conductance causes inhibited muscle relaxation after forceful voluntary contraction due to muscle membrane hyperexcitability. This represents the pathomechanism of myotonia congenita. Due to the prevailing data suggesting that...
2.
Hoppe K, Chaiklieng S, Lehmann-Horn F, Jurkat-Rott K, Wearing S, Klingler W
Pflugers Arch
. 2020 Sep;
472(10):1533.
PMID: 32885305
The original article contains an error during online publication. Table 2 was included during production round and now deleted. The Original article has been corrected.
3.
Hoppe K, Chaiklieng S, Lehmann-Horn F, Jurkat-Rott K, Wearing S, Klingler W
Pflugers Arch
. 2020 Aug;
472(10):1481-1494.
PMID: 32748018
In myotonia, reduced Cl conductance of the mutated ClC-1 channels causes hindered muscle relaxation after forceful voluntary contraction due to muscle membrane hyperexcitability. Repetitive contraction temporarily decreases myotonia, a phenomena...
4.
Zimmern V, Riant F, Roze E, Ranza E, Lehmann-Horn F, de Bellescize J, et al.
Neuropediatrics
. 2019 Jun;
50(5):308-312.
PMID: 31226716
Mutations that disrupt the presynaptic protein have been implicated in various neurological disorders including epilepsy, chronic encephalopathy, DOORS (deafness, onychodystrophy, osteodystrophy, mental retardation, and seizures) syndrome, nonsyndromic hearing loss, and...
5.
Weber M, Jurkat-Rott K, Lerche H, Lehmann-Horn F
J Neurol
. 2019 Apr;
266(7):1623-1632.
PMID: 30937521
We report a young wheelchair-dependent patient with an unclear proximal myopathy and a heterozygous, de-novo Cav1.1-R1239G mutation suggesting hypokalemic periodic paralysis (HypoPP). Sonography showed a loss of the pennate pattern...
6.
Fan C, Kuhn M, Mbiol A, Groome J, Winston V, Biskup S, et al.
Acta Myol
. 2019 Mar;
37(3):193-203.
PMID: 30838349
Introduction: Periodic paralyses (PP) are recurrent episodes of flaccid limb muscle weakness. Next to autosomal dominant forms, sporadic PP (SPP) cases are known but their genetics are unclear. Methods: In...
7.
Hoppe K, Chaiklieng S, Lehmann-Horn F, Jurkat-Rott K, Wearing S, Klingler W
J Physiol
. 2018 Oct;
597(1):225-235.
PMID: 30284249
Key Points: During myotonia congenita, reduced chloride (Cl ) conductance results in impaired muscle relaxation and increased muscle stiffness after forceful voluntary contraction. Repetitive contraction of myotonic muscle decreases or...
8.
Bayless-Edwards L, Winston V, Lehmann-Horn F, Arinze P, Groome J, Jurkat-Rott K
Sci Rep
. 2018 Jul;
8(1):10372.
PMID: 29991727
Hypokalemic periodic paralysis is a skeletal muscle disease characterized by episodic weakness associated with low serum potassium. We compared clinical and biophysical effects of R222W, the first hNa1.4 domain I...
9.
Lehmann-Horn F, DAmico A, Bertini E, Lomonaco M, Merlini L, Nelson K, et al.
Acta Myol
. 2018 May;
36(3):125-134.
PMID: 29774303
Introduction: Myotonia permanens due to Nav1.4-G1306E is a rare sodium channelopathy with potentially life-threatening respiratory complications. Our goal was to study phenotypic variability throughout life. Methods: Clinical neurophysiology and genetic...
10.
Glemser P, Jaeger H, Nagel A, Ziegler A, Simons D, Schlemmer H, et al.
Acta Myol
. 2017 Jul;
36(1):2-13.
PMID: 28690388
In this pilot study we tested whether a low dose application of a mild diuretic substance such as eplerenone is beneficial in early stages of Duchenne muscular dystrophy using Na...