Frank L Powell
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Explore the profile of Frank L Powell including associated specialties, affiliations and a list of published articles.
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57
Citations
953
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Recent Articles
1.
Ye S, Sun J, Craig S, Di Rienzo A, Witonsky D, Yu J, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(45):e2403309121.
PMID: 39432765
We chose the "natural laboratory" provided by high-altitude native ethnic Tibetan women who had completed childbearing to examine the hypothesis that multiple oxygen delivery traits were associated with lifetime reproductive...
2.
Oeung B, Pham K, Olfert I, Zerda D, Gaio E, Powell F, et al.
J Physiol
. 2023 Aug;
601(19):4423-4440.
PMID: 37589511
The hypoxic ventilatory response (HVR) is the increase in breathing in response to reduced arterial oxygen pressure. Over several decades, studies have revealed substantial population-level differences in the magnitude of...
3.
Yu J, Non A, Heinrich E, Gu W, Alcock J, Moya E, et al.
Front Physiol
. 2022 Aug;
13:885295.
PMID: 36035495
The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and biomedicine,...
4.
Keeling R, Powell F, Shaffer G, Robbins P, Simonson T
Front Physiol
. 2021 Mar;
12:571137.
PMID: 33737880
Concern is often voiced over the ongoing loss of atmospheric O. This loss, which is caused by fossil-fuel burning but also influenced by other processes, is likely to continue at...
5.
Heinrich E, Orr J, Gilbertson D, Anza-Ramirez C, DeYoung P, Djokic M, et al.
Front Physiol
. 2020 May;
11:437.
PMID: 32435207
Andean highlanders are challenged by chronic hypoxia and many exhibit elevated hematocrit (Hct) and blunted ventilation compared to other high-altitude populations. While many Andeans develop Chronic Mountain Sickness (CMS) and...
6.
Moya E, Go A, Kim C, Fu Z, Simonson T, Powell F
J Physiol
. 2020 Feb;
598(10):2021-2034.
PMID: 32026480
Key Points: We hypothesized that hypoxia inducible factor 1α (HIF-1α) in CNS respiratory centres is necessary for ventilatory acclimatization to hypoxia (VAH); VAH is a time-dependent increase in baseline ventilation...
7.
Heinrich E, Djokic M, Gilbertson D, DeYoung P, Bosompra N, Wu L, et al.
PLoS One
. 2019 Jun;
14(6):e0217089.
PMID: 31188839
Impairments in cognitive function, mood, and sleep quality occur following ascent to high altitude. Low oxygen (hypoxia) and poor sleep quality are both linked to impaired cognitive performance, but their...
8.
Moya E, Powell F
Front Physiol
. 2018 Aug;
9:860.
PMID: 30072908
Different patterns of hypoxia evoke different forms of plasticity in the neural control of ventilation. For example, acute intermittent hypoxia produces long term facilitation (LTF) of ventilation, while chronic sustained...
9.
Orr J, Heinrich E, Djokic M, Gilbertson D, DeYoung P, Anza-Ramirez C, et al.
High Alt Med Biol
. 2018 Apr;
19(2):178-184.
PMID: 29641294
Aims: Central sleep apnea (CSA) is common at high altitude, leading to desaturation and sleep disruption. We hypothesized that noninvasive ventilation using adaptive servoventilation (ASV) would be effective at stabilizing...
10.
Naji M, Komarov M, Krishnan G, Malhotra A, Powell F, Rukhadze I, et al.
J Neurophysiol
. 2018 Apr;
120(1):296-305.
PMID: 29617218
In patients with obstructive sleep apnea (OSA), the pharyngeal muscles become relaxed during sleep, which leads to a partial or complete closure of upper airway. Experimental studies suggest that withdrawal...