Frank J Castora
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Explore the profile of Frank J Castora including associated specialties, affiliations and a list of published articles.
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10
Citations
216
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Recent Articles
1.
Shelton M, Kerns K, Castora F, Coleman R
J Alzheimers Dis
. 2022 Sep;
90(1):109-117.
PMID: 36093692
Background: Alzheimer's disease is a specific form of dementia characterized by the aggregation of amyloid-β plaques and tau tangles. New research has found that the formation of these aggregates occurs...
2.
Castora F, Kerns K, Pflanzer H, Hitefield N, Gershon B, Shugoll J, et al.
J Alzheimers Dis
. 2022 Sep;
90(1):119-137.
PMID: 36093691
Background: Alzheimer's disease (AD) is a neurological disease that has both a genetic and non-genetic origin. Mitochondrial dysfunction is a critical component in the pathogenesis of AD as deficits in...
3.
Castora F, Conyers B, Gershon B, Kerns K, Campbell R, Simsek-Duran F
J Alzheimers Dis
. 2019 Sep;
72(1):257-269.
PMID: 31561357
Mitochondrial dysfunction is recognized as a critical component in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). Deficits in oxidative capacity and, specifically, cytochrome c oxidase (CO) activity have...
4.
Castora F
Prog Neuropsychopharmacol Biol Psychiatry
. 2019 Jan;
92:83-108.
PMID: 30599156
Mitochondria are the powerhouse that generate over 90% of the ATP produced in cells. In addition to its role in energy production, the mitochondrion also plays a major role in...
5.
Li F, Castora F, Ford W, Alarid K, Jones H, Swanson R
Reprod Fertil Dev
. 2016 Jun;
29(7):1384-1391.
PMID: 27327865
The hamster is a useful model of human reproductive biology because its oocytes are similar to those in humans in terms of size and structural stability. In the present study...
6.
Hsu A, Townsend P, Oehninger S, Castora F
Fertil Steril
. 2014 Dec;
103(2):347-52.e1.
PMID: 25516080
Objective: To determine whether endometriosis is associated with mitochondrial dysfunction in cumulus (granulosa [GC]) cells of subjects undergoing IVF-intracytoplasmic sperm injection (ICSI). Design: Prospective cohort study. Setting: An IVF clinic...
7.
Simsek-Duran F, Li F, Ford W, Swanson R, Jones Jr H, Castora F
PLoS One
. 2013 Jun;
8(5):e64955.
PMID: 23741435
Background: In human oocytes, as in other mammalian ova, there is a significant variation in the pregnancy potential, with approximately 20% of oocyte-sperm meetings resulting in pregnancies. This frequency of...
8.
Duran H, Simsek-Duran F, Oehninger S, Jones Jr H, Castora F
Fertil Steril
. 2011 Jun;
96(2):384-8.
PMID: 21683351
Objective: To determine the impact of reproductive aging on oocyte mitochondrial quantity, function, and DNA (mtDNA) integrity. Design: Prospective observational study. Setting: IVF clinic in a tertiary academic care center....
9.
Hermon T, Moore A, Yu L, Kissling G, Castora F, Dixon D
Virchows Arch
. 2008 Oct;
453(6):557-69.
PMID: 18853184
It is thought that the growth of uterine leiomyomas may be mediated by the interaction of estrogen receptor alpha (ERalpha) and growth factor pathways and that phosphorylation of ERalpha at...
10.
Hamblet N, Ragland B, Ali M, Conyers B, Castora F
Electrophoresis
. 2005 Dec;
27(2):398-408.
PMID: 16358358
A "mitochondrial hypothesis" of late onset Alzheimer's disease (AD) has been proposed. Biochemical studies indicate that there is a significant decrease in cytochrome oxidase (CO) activity as well as perturbed...