Frank C Tortella
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Explore the profile of Frank C Tortella including associated specialties, affiliations and a list of published articles.
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108
Citations
2763
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Recent Articles
1.
Foreman B, Lee H, Mizrahi M, Hartings J, Ngwenya L, Privitera M, et al.
Neurocrit Care
. 2021 Jul;
36(1):130-138.
PMID: 34232458
Introduction: Seizures and abnormal periodic or rhythmic patterns are observed on continuous electroencephalography monitoring (cEEG) in up to half of patients hospitalized with moderate to severe traumatic brain injury (TBI)....
2.
Witkin J, Cerne R, Newman A, Izenwasser S, Smith J, Tortella F
Pharmacol Biochem Behav
. 2021 Feb;
203:173154.
PMID: 33609599
Interest in developing NMDA receptor antagonists with reduced side-effects for neurological and psychiatric disorders has been re-energized by the recent introduction of esketamine into clinical practice for treatment-resistant depression. Structural...
3.
Lee H, Mizrahi M, Hartings J, Sharma S, Pahren L, Ngwenya L, et al.
Crit Care Med
. 2019 Jan;
47(4):574-582.
PMID: 30624278
Objectives: After traumatic brain injury, continuous electroencephalography is widely used to detect electrographic seizures. With the development of standardized continuous electroencephalography terminology, we aimed to describe the prevalence and burden...
4.
Yang Z, Zhu T, Mondello S, Akel M, Wong A, Kothari I, et al.
J Neurotrauma
. 2018 Jul;
36(2):348-359.
PMID: 29987972
Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase (UCH-L1), markers of glial and neuronal cell body injury, respectively, have been previously selected by the Operation Brain Trauma Therapy (OBTT)...
5.
Kochanek P, Bramlett H, Dixon C, Dietrich W, Mondello S, Wang K, et al.
Mil Med
. 2018 Apr;
183(suppl_1):303-312.
PMID: 29635589
Operation brain trauma therapy (OBTT) is a multi-center, pre-clinical drug and biomarker screening consortium for traumatic brain injury (TBI). Therapies are screened across three rat models (parasagittal fluid percussion injury,...
6.
Cernak I, Stein D, Elder G, Ahlers S, Curley K, DePalma R, et al.
Brain Inj
. 2017 Oct;
31(9):1168-1176.
PMID: 28981339
As a follow-up to the 2008 state-of-the-art (SOTA) conference on traumatic brain injuries (TBIs), the 2015 event organized by the United States Department of Veterans Affairs (VA) Office of Research...
7.
Johnson D, Cartagena C, Tortella F, Dave J, Schmid K, Boutte A
J Trauma Acute Care Surg
. 2017 Apr;
83(1 Suppl 1):S145-S149.
PMID: 28452880
Background: MicroRNAs (miRNAs) are small stable RNAs that regulate translational degradation or repression of genes involved in brain trauma-mediated inflammation. More recently, miRNAs have emerged as potential novel TBI biomarkers....
8.
Lu X, Cao Y, Mountney A, Liao Z, Shear D, Tortella F
J Trauma Acute Care Surg
. 2017 Apr;
83(1 Suppl 1):S25-S34.
PMID: 28452872
Background: Posttraumatic seizures are a medical problem affecting patients with traumatic brain injury. Yet effective treatment is lacking owing to the limitations of antiepileptic drugs (AEDs) applicable to these patients....
9.
Mountney A, Boutte A, Cartagena C, Flerlage W, Johnson W, Rho C, et al.
J Neurotrauma
. 2017 Mar;
34(19):2768-2789.
PMID: 28326890
Closed-head concussive injury is one of the most common causes of traumatic brain injury (TBI). Isolated concussions frequently produce acute neurological impairments, and individuals typically recover spontaneously within a short...
10.
Spurlock M, Ahmed A, Rivera K, Yokobori S, Lee S, Sam P, et al.
J Neurotrauma
. 2017 Mar;
34(11):1981-1995.
PMID: 28249550
Penetrating traumatic brain injury (PTBI) is one of the major cause of death and disability worldwide. Previous studies with penetrating ballistic-like brain injury (PBBI), a PTBI rat model revealed widespread...