Francois Bacot
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Explore the profile of Francois Bacot including associated specialties, affiliations and a list of published articles.
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33
Citations
4754
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Recent Articles
11.
Michailidou K, Beesley J, Lindstrom S, Canisius S, Dennis J, Lush M, et al.
Nat Genet
. 2015 Mar;
47(4):373-80.
PMID: 25751625
Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial risk of the disease. To identify...
12.
Orr N, Dudbridge F, Dryden N, Maguire S, Novo D, Perrakis E, et al.
Hum Mol Genet
. 2015 Feb;
24(10):2966-84.
PMID: 25652398
We recently identified a novel susceptibility variant, rs865686, for estrogen-receptor positive breast cancer at 9q31.2. Here, we report a fine-mapping analysis of the 9q31.2 susceptibility locus using 43 160 cases...
13.
Kabisch M, Lorenzo Bermejo J, Dunnebier T, Ying S, Michailidou K, Bolla M, et al.
Carcinogenesis
. 2015 Jan;
36(2):256-71.
PMID: 25586992
The chromosomal passenger complex (CPC) plays a pivotal role in the regulation of cell division. Therefore, inherited CPC variability could influence tumor development. The present candidate gene approach investigates the...
14.
Glubb D, Maranian M, Michailidou K, Pooley K, Meyer K, Kar S, et al.
Am J Hum Genet
. 2014 Dec;
96(1):5-20.
PMID: 25529635
Genome-wide association studies (GWASs) have revealed SNP rs889312 on 5q11.2 to be associated with breast cancer risk in women of European ancestry. In an attempt to identify the biologically relevant...
15.
Ghoussaini M, Edwards S, Michailidou K, Nord S, Cowper-Sal Lari R, Desai K, et al.
Nat Commun
. 2014 Sep;
4:4999.
PMID: 25248036
GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine mapping of this locus using data from 101,943 subjects from 50 case-control studies. We genotype...
16.
Lin W, Camp N, Ghoussaini M, Beesley J, Michailidou K, Hopper J, et al.
Hum Mol Genet
. 2014 Aug;
24(1):285-98.
PMID: 25168388
Previous studies have suggested that polymorphisms in CASP8 on chromosome 2 are associated with breast cancer risk. To clarify the role of CASP8 in breast cancer susceptibility, we carried out...
17.
Johnson N, Dudbridge F, Orr N, Gibson L, Jones M, Schoemaker M, et al.
Breast Cancer Res
. 2014 Jun;
16(3):R51.
PMID: 24887515
Introduction: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels...
18.
Sawyer E, Roylance R, Petridis C, Brook M, Nowinski S, Papouli E, et al.
PLoS Genet
. 2014 Apr;
10(4):e1004285.
PMID: 24743323
Invasive lobular breast cancer (ILC) accounts for 10-15% of all invasive breast carcinomas. It is generally ER positive (ER+) and often associated with lobular carcinoma in situ (LCIS). Genome-wide association...
19.
Couch F, Wang X, McGuffog L, Lee A, Olswold C, Kuchenbaecker K, et al.
PLoS Genet
. 2013 Apr;
9(3):e1003212.
PMID: 23544013
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom...
20.
Gaudet M, Kuchenbaecker K, Vijai J, Klein R, Kirchhoff T, McGuffog L, et al.
PLoS Genet
. 2013 Apr;
9(3):e1003173.
PMID: 23544012
Common genetic variants contribute to the observed variation in breast cancer risk for BRCA2 mutation carriers; those known to date have all been found through population-based genome-wide association studies (GWAS)....