Francesco Gubinelli
Overview
Explore the profile of Francesco Gubinelli including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
160
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0
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Recent Articles
1.
Ekimov A, Arunachalam A, Blake T, Bodle J, Couzens L, Dubey S, et al.
Vaccine
. 2023 Jun;
41(32):4639-4647.
PMID: 37344260
Determination of the potency of a vaccine is critical to ensuring that an appropriate dose is delivered, lot-to-lot consistency is maintained, and that the formulation is stable over the life...
2.
Anwer D, Gubinelli F, Kurt Y, Sarauskyte L, Jacobs F, Venuti C, et al.
PLoS One
. 2023 May;
18(5):e0284480.
PMID: 37126506
Microglial cells are brain-specific macrophages that swiftly react to disruptive events in the brain. Microglial activation leads to specific modifications, including proliferation, morphological changes, migration to the site of insult,...
3.
Quintino L, Gubinelli F, Sarauskyte L, Arvidsson E, Davidsson M, Lundberg C, et al.
J Neurosci Methods
. 2022 Jun;
378:109640.
PMID: 35690332
Background: The development of axonal pathology is a key characteristic of many neurodegenerative disease such as Parkinson's disease and Alzheimer's disease. With advanced disease progression, affected axons do display several...
4.
Negrini M, Tomasello G, Davidsson M, Fenyi A, Adant C, Hauser S, et al.
J Parkinsons Dis
. 2022 Feb;
12(4):1133-1153.
PMID: 35213388
Background: Preclinical rodent models for Parkinson's disease (PD) based on viral human alpha-synuclein (h-αSyn) overexpression recapitulate some of the pathological hallmarks as it presents in humans, such as progressive cell...
5.
Van Camp N, Lavisse S, Roost P, Gubinelli F, Hillmer A, Boutin H
Eur J Nucl Med Mol Imaging
. 2021 Jul;
49(1):77-109.
PMID: 34245328
Over the last 30 years, the 18-kDa TSPO protein has been considered as the PET imaging biomarker of reference to measure increased neuroinflammation. Generally assumed to image activated microglia, TSPO...
6.
Cresto N, Gardier C, Gaillard M, Gubinelli F, Roost P, Molina D, et al.
Int J Mol Sci
. 2021 Jul;
22(13).
PMID: 34201785
Alpha-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) play crucial roles in Parkinson's disease (PD). They may functionally interact to induce the degeneration of dopaminergic (DA) neurons via mechanisms that...
7.
Rebelo A, Gubinelli F, Roost P, Jan C, Brouillet E, Van Camp N, et al.
J Neuroinflammation
. 2021 May;
18(1):116.
PMID: 33993882
Background: Neuroinflammation is an underlying pathology of all neurological conditions, the understanding of which is still being comprehended. A specific molecular pathway that has been overlooked in neuroinflammation is glycosylation...
8.
Cresto N, Gaillard M, Gardier C, Gubinelli F, Diguet E, Bellet D, et al.
Neurobiol Dis
. 2019 Oct;
134:104614.
PMID: 31605779
The G2019S substitution in the kinase domain of LRRK2 (LRRK2) is the most prevalent mutation associated with Parkinson's disease (PD). Neurotoxic effects of LRRK2 are thought to result from an...
9.
Duralliu A, Matejtschuk P, Dubey S, Koroma H, Gubinelli F, Williams D
Vaccine
. 2019 Jul;
37(32):4485-4490.
PMID: 31277955
Low moisture content is seen as crucial to achieving long term stability of freeze dried biologics and reference materials. Highly hygroscopic freeze-dried material are susceptible to moisture ingress over time...
10.
Cresto N, Gardier C, Gubinelli F, Gaillard M, Liot G, West A, et al.
Eur J Neurosci
. 2018 Oct;
49(3):339-363.
PMID: 30269383
Our understanding of the mechanisms underlying Parkinson's disease, the once archetypical nongenetic neurogenerative disorder, has dramatically increased with the identification of α-synuclein and LRRK2 pathogenic mutations. While α-synuclein protein composes...