Francesca Pierige
Overview
Explore the profile of Francesca Pierige including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
198
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0
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Recent Articles
1.
Pampalone G, Chiasserini D, Pierige F, Camaioni E, Orvietani P, Bregalda A, et al.
Int J Mol Sci
. 2024 Jul;
25(14).
PMID: 39063173
The gyrate atrophy of the choroid and retina (GACR) is a rare genetic disease for which no definitive cure is available. GACR is due to the deficit of ornithine aminotransferase...
2.
Bregalda A, Carducci C, Pascucci T, Ambrogini P, Sartini S, Pierige F, et al.
Mol Genet Metab
. 2024 Jul;
143(1-2):108543.
PMID: 39047302
Phenylketonuria (PKU, OMIM 261600) is a genetic disorder caused by a deficiency of the hepatic enzyme phenylalanine hydroxylase (PAH). If left untreated, PKU leads to systemic phenylalanine (Phe) accumulation, which...
3.
Bianchi M, Rossi L, Pierige F, Biagiotti S, Bregalda A, Tasini F, et al.
Expert Opin Drug Deliv
. 2023 May;
20(7):921-935.
PMID: 37249524
Introduction: We have previously described the preclinical developments in enzyme-loaded red blood cells to be used in the treatment of several rare diseases, as well as in chronic conditions. Area...
4.
Bregalda A, Carducci C, Viscomi M, Pierige F, Biagiotti S, Menotta M, et al.
Neurobiol Dis
. 2023 Mar;
180:106093.
PMID: 36948260
Untreated phenylketonuria (PKU) patients and PKU animal models show hypomyelination in the central nervous system and white matter damages, which are accompanied by myelin basic protein (MBP) impairment. Despite many...
5.
Bianchi M, Rossi L, Pierige F, De Angeli P, Aliano M, Carducci C, et al.
Mol Ther Methods Clin Dev
. 2022 Mar;
25:26-40.
PMID: 35317049
Here we report, for the first time, the engineering of human red blood cells (RBCs) with an entire metabolic pathway as a potential strategy to treat patients with guanidinoacetate methyltransferase...
6.
Rossi L, Nardecchia F, Pierige F, Ventura R, Carducci C, Leuzzi V, et al.
Genes (Basel)
. 2021 Aug;
12(8).
PMID: 34440375
Guanidinoacetate methyltransferase deficiency (GAMT-D) is one of three cerebral creatine (Cr) deficiency syndromes due to pathogenic variants in the GAMT gene (19p13.3). GAMT-D is characterized by the accumulation of guanidinoacetic...
7.
Rossi L, Pierige F, Agostini M, Bigini N, Termopoli V, Cai Y, et al.
Front Physiol
. 2020 Oct;
11:573492.
PMID: 33013487
Recombinant bacterial cocaine esterase (CocE) represents a potential protein therapeutic for cocaine use disorder treatment. Unfortunately, the native enzyme was highly unstable and the corresponding mutagenized derivatives, RBP-8000 and E196-301,...
8.
Rossi L, Pierige F, Bregalda A, Magnani M
Expert Opin Drug Deliv
. 2020 Sep;
18(1):43-54.
PMID: 32924643
Introduction: Therapeutic enzymes are currently used in the treatment of several diseases. In most cases, the benefits are limited due to poor stability, immunogenicity, and drug-induced inactivating antibodies. A partial...
9.
Fraternale A, Zara C, Pierige F, Rossi L, Ligi D, Amagliani G, et al.
Int J Antimicrob Agents
. 2020 Aug;
56(4):106148.
PMID: 32853674
Despite early treatment with antimycobacterial combination therapy, drug resistance continues to emerge. Maintenance of redox homeostasis is essential for Mycobacterium avium (M. avium) survival and growth. The aim of the...
10.
Rossi L, Pierige F, Aliano M, Magnani M
BioDrugs
. 2020 Mar;
34(3):265-272.
PMID: 32198632
Engineered red blood cells (RBCs) appear to be a promising method for therapeutic drug and protein delivery. With a number of agents in clinical trials (e.g., dexamethasone 21-phosphate in ataxia...