Francesca Natale
Overview
Explore the profile of Francesca Natale including associated specialties, affiliations and a list of published articles.
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16
Citations
224
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Recent Articles
1.
Natale F, Spinelli M, Rinaudo M, Gulisano W, Nifo Sarrapochiello I, Aceto G, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(49):e2402604121.
PMID: 39589870
Protein post-translational modifications (PTM) play a crucial role in the modulation of synaptic function and their alterations are involved in the onset and progression of neurodegenerative disorders. S-palmitoylation is a...
2.
Bandiera B, Natale F, Rinaudo M, Sollazzo R, Spinelli M, Fusco S, et al.
Brain Commun
. 2024 Nov;
6(6):fcae390.
PMID: 39564126
Acute and chronic stress markedly affects behavior by triggering sympathetic nervous system activation and several hypothalamus-pituitary-adrenal-dependent responses. Brain regions of the limbic system are responsible for the regulation of stress...
3.
Spinelli M, Spallotta F, Cencioni C, Natale F, Re A, Dellaria A, et al.
Sci Rep
. 2024 Aug;
14(1):19651.
PMID: 39179650
Metabolic disorders such as insulin resistance and type 2 diabetes are associated with brain dysfunction and cognitive deficits, although the underpinning molecular mechanisms remain elusive. Epigenetic factors, such as non-coding...
4.
Natale F, Spinelli M, Rinaudo M, Cocco S, Nifo Sarrapochiello I, Fusco S, et al.
Cells
. 2023 Jan;
12(2).
PMID: 36672155
Maternal overnutrition has been reported to affect brain plasticity of the offspring by altering gene expression, regulating both synaptic plasticity and adult neurogenesis. However, whether perinatal metabolic stress may influence...
5.
Natale F, Fusco S, Grassi C
Transl Neurodegener
. 2022 Nov;
11(1):50.
PMID: 36437458
Neurodegenerative disorders are one of the most common causes of disability and represent 6.3% of the global burden of disease. Among them, Alzheimer's, Parkinson's, and Huntington's diseases cause cognitive decline,...
6.
Natale F, Spinelli M, Barbati S, Leone L, Fusco S, Grassi C
Cells
. 2022 Sep;
11(17).
PMID: 36078069
Early-life metabolic stress has been demonstrated to affect brain development, persistently influence brain plasticity and to exert multigenerational effects on cognitive functions. However, the impact of an ancestor's diet on...
7.
Rinaudo M, Natale F, La Greca F, Spinelli M, Farsetti A, Paciello F, et al.
Biomedicines
. 2022 Jun;
10(6).
PMID: 35740410
Despite being a crucial physiological function of the brain, the mechanisms underlying forgetting are still poorly understood. Estrogens play a critical role in different brain functions, including memory. However, the...
8.
Natale F, Leone L, Rinaudo M, Sollazzo R, Barbati S, La Greca F, et al.
Stem Cells
. 2022 Mar;
40(3):318-331.
PMID: 35356985
Neural stem and progenitor cell (NSPC) depletion may play a crucial role in the cognitive impairment observed in many age-related non-communicable diseases. Insulin resistance affects brain functions through a plethora...
9.
Zuliani I, Lanzillotta C, Tramutola A, Barone E, Perluigi M, Rinaldo S, et al.
Int J Mol Sci
. 2021 Apr;
22(7).
PMID: 33916835
The disturbance of protein O-GlcNAcylation is emerging as a possible link between altered brain metabolism and the progression of neurodegeneration. As observed in brains with Alzheimer's disease (AD), flaws of...
10.
Spinelli M, Natale F, Rinaudo M, Leone L, Mezzogori D, Fusco S, et al.
Int J Mol Sci
. 2020 Dec;
21(23).
PMID: 33256199
Overnutrition and metabolic disorders impair cognitive functions through molecular mechanisms still poorly understood. In mice fed with a high fat diet (HFD) we analysed the expression of synaptic plasticity-related genes...