Francesca Clemente
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Explore the profile of Francesca Clemente including associated specialties, affiliations and a list of published articles.
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30
Citations
175
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Recent Articles
1.
Tagliaferro G, Davighi M, Clemente F, Turchi F, Schiavina M, Matassini C, et al.
ACS Chem Neurosci
. 2025 Mar;
PMID: 40079830
Intrinsically disordered proteins (IDPs) are highly flexible molecules often linked to the onset of incurable diseases. Despite their great therapeutic potential, IDPs are often considered as undruggable because they lack...
2.
Buco F, Clemente F, Morrone A, Vanni C, Moya S, Cardona F, et al.
Bioconjug Chem
. 2024 Dec;
36(1):92-103.
PMID: 39700399
The present study reports the preparation of the first multivalent iminosugars built onto a glyco-gold nanoparticle core (glyco-AuNPs) capable of stabilizing or enhancing the activity of the lysosomal enzyme GCase,...
3.
Davighi M, Clemente F, Andreasen E, Brondsted Nielsen M, Matassini C, Goti A, et al.
Chem Biodivers
. 2024 Jun;
21(8):e202401104.
PMID: 38847390
A remarkable enhancer of human glucocerebrosidase enzyme (GCase) was identified among a set of dihydroazulene-tagged iminosugars. An unprecedented 3.9-fold increase in GCase activity was detected on fibroblasts bearing the homozygous...
4.
Galeota E, Bevilacqua V, Gobbini A, Gruarin P, Bombaci M, Pesce E, et al.
Clin Immunol
. 2024 Feb;
261:110164.
PMID: 38417765
Multiple vaccines have been approved to control COVID-19 pandemic, with Pfizer/BioNTech (BNT162b2) being widely used. We conducted a longitudinal analysis of the immune response elicited after three doses of the...
5.
Pulvirenti N, Silvetri Y, Clemente F, Bosotti R, Carelli E, Moschetti G, et al.
Eur J Immunol
. 2024 Feb;
54(4):e2350675.
PMID: 38396108
Human CD4EOMES T cells are heterogeneous and contain Th1-cells, Tr1-cells, and CD4CTL. Tr1- cells and non-classical EOMES Th1-cells displayed, respectively, anti- and pro-inflammatory cytokine profiles, but both expressed granzyme-K, produced...
6.
Ceni C, Clemente F, Mangiavacchi F, Matassini C, Tonin R, Caciotti A, et al.
Molecules
. 2024 Jan;
29(2).
PMID: 38257371
Gaucher disease (GD) is a rare genetic metabolic disorder characterized by a dysfunction of the lysosomal glycoside hydrolase glucocerebrosidase (GCase) due to mutations in the gene GBA1, leading to the...
7.
Buco F, Matassini C, Vanni C, Clemente F, Paoli P, Carozzini C, et al.
Org Biomol Chem
. 2023 Nov;
21(47):9362-9371.
PMID: 37975191
-Acetylgalactosamine-6-sulfatase (GALNS) is an enzyme whose deficiency is related to the lysosomal storage disease Morquio A. For the development of effective therapeutic approaches against this disease, the design of suitable...
8.
Davighi M, Matassini C, Clemente F, Paoli P, Morrone A, Cacciarini M, et al.
Chembiochem
. 2023 Oct;
25(1):e202300730.
PMID: 37877519
Engineering bioactive iminosugars with pH-responsive groups is an emerging approach to develop pharmacological chaperones (PCs) able to improve lysosomal trafficking and enzymatic activity rescue of mutated enzymes. The use of...
9.
De Monte L, Clemente F, Ruggiero E, Pini R, Ceraolo M, Schiavo Lena M, et al.
EBioMedicine
. 2023 Sep;
97:104819.
PMID: 37776595
Background: Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis and it is characterized by predominant pro-tumor Th2-type inflammation. T follicular helper (Tfh) cells are relevant immunoregulators in cancer, and often...
10.
Martinez-Bailen M, Matassini C, Clemente F, Faggi C, Goti A, Cardona F
Org Lett
. 2023 Jul;
25(31):5833-5837.
PMID: 37515782
A novel stereoselective synthetic approach to pentahydroxyazepane iminosugars is described. The strategy relies on a key osmium-catalyzed aminohydroxylation reaction of allylic alcohols obtained via addition of vinylmagnesium bromide to a...