Frances N Shirota
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Explore the profile of Frances N Shirota including associated specialties, affiliations and a list of published articles.
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3
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22
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Recent Articles
1.
Berkeley L, Cohen J, Crankshaw D, Shirota F, Nagasawa H
J Biochem Mol Toxicol
. 2003 Apr;
17(2):95-7.
PMID: 12717742
L-Cysteine-glutathione disulfide, a ubiquitous substance present in mammalian cells, was shown to be highly effective in protecting mice against acetaminophen-induced hepatotoxicity. Since the corresponding D-cysteine-glutathione disulfide was totally ineffective in...
2.
Crankshaw D, Berkeley L, Cohen J, Shirota F, Nagasawa H
J Biochem Mol Toxicol
. 2002 Nov;
16(5):235-44.
PMID: 12439865
A series of double-prodrugs of L-cysteine, designed to release L-cysteine in vivo and stimulate the biosynthesis of glutathione (GSH), were synthesized. To evaluate the hepatoprotective effectiveness of these double-prodrugs, male...
3.
Shirota F, DeMaster E, Shoeman D, Nagasawa H
Toxicol Lett
. 2002 Jun;
132(1):1-8.
PMID: 12084614
Administration of acetaminophen (ACP, 400 mg/kg, i.p.) to fasted, male Swiss-Webster mice caused a rapid 90% decrease in total hepatic glutathione (GSH) and a 58% decrease in mitochondrial GSH by...