Florian J Bock
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Explore the profile of Florian J Bock including associated specialties, affiliations and a list of published articles.
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20
Citations
1255
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Recent Articles
11.
Bock F, Chang P
FEBS J
. 2016 Apr;
283(22):4017-4031.
PMID: 27087568
Poly(ADP-ribose) polymerases (PARPs) regulate the function of target proteins by modifying them with ADP-ribose, a large and unique post-translational modification. Humans express 17 PARPs; however, historically, much of the focus...
12.
Bock F, Todorova T, Chang P
Mol Cell
. 2015 Jun;
58(6):959-69.
PMID: 26091344
Posttranscriptional regulation of RNA facilitates the fine-tuning of gene expression. It occurs through multiple pathways that include the nuclear processing of mRNA and its precursors, mRNA silencing, regulation of mRNA...
13.
Bock F, Tanzer M, Haschka M, Krumschnabel G, Sohm B, Goetsch K, et al.
Sci Rep
. 2015 Jun;
5:11268.
PMID: 26062895
The tumour suppressor p53 is an important mediator of cell cycle arrest and apoptosis in response to DNA damage, acting mainly by transcriptional regulation of specific target genes. The exact...
14.
Bock F, Chang P
Chem Biol
. 2015 Apr;
22(4):432-433.
PMID: 25910238
The inflammatory response is a critical component of the immune system that is activated by stimuli such as cytokines, foreign DNA, RNA, or other harmful substances. Krukenberg et al. (2015)...
15.
Todorova T, Bock F, Chang P
Trends Mol Med
. 2015 Apr;
21(6):373-84.
PMID: 25851173
Post-transcriptional regulation of RNA is an important mechanism for activating and resolving cellular stress responses. Poly(ADP-ribose) polymerase-13 (PARP13), also known as ZC3HAV1 and zinc-finger antiviral protein (ZAP), is an RNA-binding...
16.
17.
Todorova T, Bock F, Chang P
Nat Commun
. 2014 Nov;
5:5362.
PMID: 25382312
Poly(ADP-ribose) polymerase-13 (PARP13/ZAP/ZC3HAV1) is an antiviral factor, active against specific RNA viruses such as murine leukaemia virus, Sindbis virus and human immunodeficiency virus. During infection, PARP13 binds viral RNA via...
18.
Fava L, Bock F, Geley S, Villunger A
J Cell Sci
. 2013 Mar;
125(Pt 24):5911-5.
PMID: 23447670
No abstract available.
19.
Labi V, Bertele D, Woess C, Tischner D, Bock F, Schwemmers S, et al.
EMBO Mol Med
. 2012 Nov;
5(1):122-36.
PMID: 23180554
Anti-apoptotic Bcl-2 family members are critical for the regulation of haematopoietic stem and progenitor cell (HSPC) survival. Little is known about the role of their pro-apoptotic antagonists, i.e. 'BH3-only' proteins,...
20.
Bock F, Villunger A
Mol Cell
. 2011 Jun;
42(5):555-6.
PMID: 21658596
Knowledge about "life vs. death" decisions made by p53 after DNA damage is limited but critical to preventing side effects during therapeutic application and to improve anticancer activity. Here, Charvet...