Florentia M Smith
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Explore the profile of Florentia M Smith including associated specialties, affiliations and a list of published articles.
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6
Citations
323
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Recent Articles
1.
Moorwood K, Smith F, Garfield A, Cowley M, Holt L, Daly R, et al.
BMC Biol
. 2024 Sep;
22(1):221.
PMID: 39343875
Background: The growth factor receptor bound protein 7 (Grb7) family of signalling adaptor proteins comprises Grb7, Grb10 and Grb14. Each can interact with the insulin receptor and other receptor tyrosine...
2.
Moorwood K, Smith F, Garfield A, Ward A
BMC Biol
. 2024 May;
22(1):127.
PMID: 38816743
Background: Optimal size at birth dictates perinatal survival and long-term risk of developing common disorders such as obesity, type 2 diabetes and cardiovascular disease. The imprinted Grb10 gene encodes a...
3.
Garfield A, Cowley M, Smith F, Moorwood K, Stewart-Cox J, Gilroy K, et al.
Nature
. 2011 Jan;
469(7331):534-8.
PMID: 21270893
Imprinted genes, defined by their preferential expression of a single parental allele, represent a subset of the mammalian genome and often have key roles in embryonic development, but also postnatal...
4.
Charalambous M, Cowley M, Geoghegan F, Smith F, Radford E, Marlow B, et al.
Dev Biol
. 2009 Oct;
337(1):1-8.
PMID: 19833122
The control of foetal growth is poorly understood and yet it is critically important that at birth the body has attained appropriate size and proportions. Growth and survival of the...
5.
Smith F, Holt L, Garfield A, Charalambous M, Koumanov F, Perry M, et al.
Mol Cell Biol
. 2007 Jun;
27(16):5871-86.
PMID: 17562854
The Grb10 adapter protein is capable of interacting with a variety of receptor tyrosine kinases, including, notably, the insulin receptor. Biochemical and cell culture experiments have indicated that Grb10 might...
6.
Charalambous M, Smith F, Bennett W, Crew T, Mackenzie F, Ward A
Proc Natl Acad Sci U S A
. 2003 Jun;
100(14):8292-7.
PMID: 12829789
To investigate the function of the Grb10 adapter protein, we have generated mice in which the Grb10 gene was disrupted by a gene-trap insertion. Our experiments confirm that Grb10 is...