Flavio Fracasso
Overview
Explore the profile of Flavio Fracasso including associated specialties, affiliations and a list of published articles.
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19
Citations
517
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0
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Recent Articles
1.
Chimienti G, Picca A, Fracasso F, Russo F, Orlando A, Riezzo G, et al.
Int J Mol Sci
. 2021 Feb;
22(4).
PMID: 33562258
Calorie restriction (CR) is the most efficacious treatment to delay the onset of age-related changes such as mitochondrial dysfunction. However, the sensitivity of mitochondrial markers to CR and the age-related...
2.
Deletion of OGG1 Results in a Differential Signature of Oxidized Purine Base Damage in mtDNA Regions
Chimienti G, Pesce V, Fracasso F, Russo F, de Souza-Pinto N, Bohr V, et al.
Int J Mol Sci
. 2019 Jul;
20(13).
PMID: 31284385
Mitochondrial oxidative stress accumulates with aging and age-related diseases and induces alterations in mitochondrial DNA (mtDNA) content. Since mtDNA qualitative alterations are also associated with aging, repair of mtDNA damage...
3.
Chimienti G, Picca A, Fracasso F, Marzetti E, Calvani R, Leeuwenburgh C, et al.
Int J Mol Sci
. 2019 May;
20(10).
PMID: 31137890
While mitochondrial dysfunction is acknowledged as a major feature of aging, much less is known about the role of mitochondria in extended longevity. Livers from aged (28-month-old) and extremely aged...
4.
An In Vitro Study on Mitochondrial Compensatory Response Induced by Gliadin Peptides in Caco-2 Cells
Orlando A, Chimienti G, Pesce V, Fracasso F, Lezza A, Russo F
Int J Mol Sci
. 2019 Apr;
20(8).
PMID: 30991726
Dietary gliadin may show a broad spectrum of toxicity. The interplay between mitochondria and gliadin-induced oxidative stress has not been thoroughly examined in the intestinal epithelium. In this kinetic study,...
5.
Chimienti G, Picca A, Sirago G, Fracasso F, Calvani R, Bernabei R, et al.
Free Radic Biol Med
. 2018 Jul;
124:447-453.
PMID: 29969715
The well-known age-related mitochondrial dysfunction deeply affects heart because of the tissue's large dependence on mitochondrial ATP provision. Our study revealed in aged rat heart a significant 25% decrease in...
6.
Sirago G, Conte E, Fracasso F, Cormio A, Fehrentz J, Martinez J, et al.
Sci Rep
. 2017 Oct;
7(1):13017.
PMID: 29026190
Chemotherapy can cause cachexia, which consists of weight loss associated with muscle atrophy. The exact mechanisms underlying this skeletal muscle toxicity are largely unknown and co-therapies to attenuate chemotherapy-induced side...
7.
Nicassio L, Fracasso F, Sirago G, Musicco C, Picca A, Marzetti E, et al.
Exp Gerontol
. 2017 Aug;
98:99-109.
PMID: 28807823
We previously reported the ability of dietary supplementation with acetyl-l-carnitine (ALCAR) to prevent age-related decreases of mitochondrial biogenesis in skeletal muscle and liver of old rats. Here, we investigate the...
8.
Picca A, Pesce V, Sirago G, Fracasso F, Leeuwenburgh C, Lezza A
Exp Gerontol
. 2016 Sep;
85:33-40.
PMID: 27620821
Extremely interesting for aging research are those individuals able to reach older ages still with functions similar to those of younger counterparts. We examined liver samples from ad libitum-fed old...
9.
Picca A, Pesce V, Fracasso F, Joseph A, Leeuwenburgh C, Lezza A
Biochim Biophys Acta
. 2014 Mar;
1840(7):2184-91.
PMID: 24631828
Background: Mitochondrial Transcription Factor A (TFAM) is regarded as a histone-like protein of mitochondrial DNA (mtDNA), performing multiple functions for this genome. Aging affects mitochondria in a tissue-specific manner and...
10.
Giordano C, Iommarini L, Giordano L, Maresca A, Pisano A, Valentino M, et al.
Brain
. 2013 Dec;
137(Pt 2):335-53.
PMID: 24369379
Leber's hereditary optic neuropathy is a maternally inherited blinding disease caused as a result of homoplasmic point mutations in complex I subunit genes of mitochondrial DNA. It is characterized by...