Flavia R S Lima
Overview
Explore the profile of Flavia R S Lima including associated specialties, affiliations and a list of published articles.
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Articles
20
Citations
485
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Recent Articles
1.
Leardini-Tristao M, Andrade G, Garcia C, Reis P, Lourenco M, Moreira E, et al.
J Neuroinflammation
. 2024 Jun;
21(1):160.
PMID: 38902739
No abstract available.
2.
Vieira C, Lelis C, Ochioni A, Rosario D, Rosario I, Vieira I, et al.
Biomed Pharmacother
. 2024 Jun;
177:116884.
PMID: 38889635
Nonsteroidal anti-inflammatory drugs (NSAIDs) regulate inflammation, which is associated with their role in preventing neurodegenerative diseases in epidemiological studies. It has sparked interest in their unconventional application for reducing neuroinflammation,...
3.
de Camargo Magalhaes E, de Bont E, Bruggeman S, Lima F
Biochim Biophys Acta Mol Basis Dis
. 2024 May;
1870(6):167248.
PMID: 38777100
Recent studies in Diffuse Midline Gliomas (DMG) demonstrated a strong connection between epigenome dysregulation and metabolic rewiring. Here, we evaluated the value of targeting a glycolytic protein named Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase 3...
4.
Lima J, R Costa T, da Fonseca A, do Amaral R, Nascimento M, Santos-Filho O, et al.
Bioorg Chem
. 2020 Sep;
104:104215.
PMID: 32920358
Due to the lack of effective pharmacotherapy options to treats Alzheimer's disease, new strategies have been approached in the search for multi-target molecules as therapeutic options. In this work, four...
5.
Zanon V, Lima J, Amaral R, Lima F, Kitagawa D, Franca T, et al.
J Biomol Struct Dyn
. 2020 Jul;
39(16):6112-6125.
PMID: 32715924
In search of a novel class of compounds against Alzheimer's disease (AD), a new series of 7-chloro-aminoquinoline derivatives containing methylene spacers of different sizes between the 7-chloro-4-aminoquinoline nucleus and imino...
6.
Amaral R, Geraldo L, Einicker-Lamas M, E Spohr T, Mendes F, Lima F
J Neurochem
. 2020 May;
156(4):499-512.
PMID: 32438456
Glioblastomas (GBMs) are highly aggressive primary brain tumors characterized by cellular heterogeneity, insensitivity to chemotherapy and poor patient survival. Lysophosphatidic acid (LPA) is a lysophospholipid that acts as a bioactive...
7.
Leardini-Tristao M, Andrade G, Garcia C, Reis P, Lourenco M, Moreira E, et al.
J Neuroinflammation
. 2020 Apr;
17(1):117.
PMID: 32299450
Background: Brain circulation disorders such as chronic cerebral hypoperfusion have been associated with a decline in cognitive function during the development of dementia. Astrocytes together with microglia participate in the...
8.
Pedrote M, Motta M, Ferretti G, Norberto D, Spohr T, Lima F, et al.
iScience
. 2020 Jan;
23(2):100820.
PMID: 31981923
Tumor-associated p53 mutations endow cells with malignant phenotypes, including chemoresistance. Amyloid-like oligomers of mutant p53 transform this tumor suppressor into an oncogene. However, the composition and distribution of mutant p53...
9.
Zanon V, Lima J, Cuya T, Lima F, da Fonseca A, Gomez J, et al.
J Inorg Biochem
. 2018 Dec;
191:183-193.
PMID: 30530179
Alzheimer's disease (AD) is one of the most common age-related neurodegenerative disorders. Aggregation of amyloid-β peptide into extracellular plaques with incorporation of metal ions, such as Cu, and reduction of...
10.
Matias D, Balca-Silva J, da Graca G, Wanjiru C, Macharia L, Nascimento C, et al.
Front Cell Neurosci
. 2018 Aug;
12:235.
PMID: 30123112
In recent years, the functions of glial cells, namely, astrocytes and microglia, have gained prominence in several diseases of the central nervous system, especially in glioblastoma (GB), the most malignant...