Fionn OHara
Overview
Explore the profile of Fionn OHara including associated specialties, affiliations and a list of published articles.
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12
Citations
409
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Recent Articles
1.
Hentsch A, Guberman M, Radetzki S, Kaushik S, Huizenga M, He Y, et al.
J Am Chem Soc
. 2025 Mar;
PMID: 40063733
Monoacylglycerol lipase (MAGL) is the pivotal catabolic enzyme responsible for signal termination in the endocannabinoid system. Inhibition of MAGL offers unique advantages over the direct activation of cannabinoid receptors in...
2.
Gazzi T, Brennecke B, Olikauskas V, Hochstrasser R, Wang H, Keen Chao S, et al.
Chembiochem
. 2024 Nov;
26(6):e202400704.
PMID: 39607084
Cell-free enzymatic assays are highly useful tools in early compound profiling due to their robustness and scalability. However, their inadequacy to reflect the complexity of target engagement in a cellular...
3.
Kuhn B, Ritter M, Hornsperger B, Bell C, Kocer B, Rombach D, et al.
J Med Chem
. 2024 Oct;
67(20):18448-18464.
PMID: 39360636
Monoacylglycerol lipase (MAGL) is a key enzyme involved in the metabolism of the endogenous signaling ligand 2-arachidonoylglycerol, a neuroprotective endocannabinoid intimately linked to central nervous system (CNS) disorders associated with...
4.
Aebi J, Atz K, Ametamey S, Benz J, Blaising J, Butini S, et al.
Chimia (Aarau)
. 2024 Sep;
78(7-8):499-512.
PMID: 39221845
The endocannabinoid system (ECS) is a critical regulatory network composed of endogenous cannabinoids (eCBs), their synthesizing and degrading enzymes, and associated receptors. It is integral to maintaining homeostasis and orchestrating...
5.
He Y, Kramer S, Grether U, Wittwer M, Collin L, Kuhn B, et al.
J Nucl Med
. 2024 Jan;
65(2):300-305.
PMID: 38164615
This study aimed to evaluate ()-[F]YH134 as a novel PET tracer for imaging monoacylglycerol lipase (MAGL). Considering the ubiquitous expression of MAGL throughout the whole body, the impact of various...
6.
He Y, Gobbi L, Muller Herde A, Rombach D, Ritter M, Kuhn B, et al.
Nucl Med Biol
. 2022 Mar;
108-109:24-32.
PMID: 35248850
Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays an important role in the endocannabinoid degradation in the brain. It has recently emerged as a promising therapeutic target in the...
7.
Pitts A, OHara F, Snell R, Gaunt M
Angew Chem Int Ed Engl
. 2015 Feb;
54(18):5451-5.
PMID: 25706658
A sequential CH functionalization strategy for the synthesis of the marine alkaloid dictyodendrin B is reported. Our synthesis begins from commercially available 4-bromoindole and involves six direct functionalizations around the...
8.
OHara F, Burns A, Collins M, Dalvie D, Ornelas M, Vaz A, et al.
J Med Chem
. 2014 Jan;
57(4):1616-20.
PMID: 24472070
The bioavailability of aromatic azaheterocyclic drugs can be affected by the activity of aldehyde oxidase (AO). Susceptibility to AO metabolism is difficult to predict computationally and can be complicated in...
9.
OHara F, Blackmond D, Baran P
J Am Chem Soc
. 2013 Jul;
135(32):12122-34.
PMID: 23859263
Radical addition processes can be ideally suited for the direct functionalization of heteroaromatic bases, yet these processes are only sparsely used due to the perception of poor or unreliable control...
10.
OHara F, Baxter R, OBrien A, Collins M, Dixon J, Fujiwara Y, et al.
Nat Protoc
. 2013 May;
8(6):1042-7.
PMID: 23640168
The present protocol details the synthesis of zinc bis(alkanesulfinate)s that can be used as general reagents for the formation of radical species. The zinc sulfinates described herein are generated from...