Fiona L Kearns
Overview
Explore the profile of Fiona L Kearns including associated specialties, affiliations and a list of published articles.
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27
Citations
742
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Recent Articles
1.
Tse A, Acreman C, Ricardo-Lax I, Berrigan J, Lasso G, Balogun T, et al.
PLoS Pathog
. 2024 Nov;
20(11):e1012704.
PMID: 39546542
Understanding the zoonotic risks posed by bat coronaviruses (CoVs) is critical for pandemic preparedness. Herein, we generated recombinant vesicular stomatitis viruses (rVSVs) bearing spikes from divergent bat CoVs to investigate...
2.
Kearns F, Rosenfeld M, Amaro R
J Chem Inf Model
. 2024 Sep;
64(20):7949-7965.
PMID: 39327869
Mucins, the biomolecular components of mucus, are glycoproteins that form a thick physical barrier at all tissue-air interfaces, forming a first line of defense against pathogens. Structural features of mucins...
3.
Hwang W, Austin S, Blondel A, Boittier E, Boresch S, Buck M, et al.
J Phys Chem B
. 2024 Sep;
128(41):9976-10042.
PMID: 39303207
Since its inception nearly a half century ago, CHARMM has been playing a central role in computational biochemistry and biophysics. Commensurate with the developments in experimental research and advances in...
4.
Nuqui X, Casalino L, Zhou L, Shehata M, Wang A, Tse A, et al.
Nat Commun
. 2024 Aug;
15(1):7370.
PMID: 39191724
The full-length prefusion-stabilized SARS-CoV-2 spike (S) is the principal antigen of COVID-19 vaccines. Vaccine efficacy has been impacted by emerging variants of concern that accumulate most of the sequence modifications...
5.
Tse A, Acreman C, Ricardo-Lax I, Berrigan J, Lasso G, Balogun T, et al.
bioRxiv
. 2024 Jul;
PMID: 38979151
Understanding the zoonotic risks posed by bat coronaviruses (CoVs) is critical for pandemic preparedness. Herein, we generated recombinant vesicular stomatitis viruses (rVSVs) bearing spikes from divergent bat CoVs to investigate...
6.
Li J, Zhang O, Sun K, Wang Y, Guan X, Bagni D, et al.
J Chem Inf Model
. 2024 Jun;
64(24):9082-9097.
PMID: 38843070
Determining the viability of a new drug molecule is a time- and resource-intensive task that makes computer-aided assessments a vital approach to rapid drug discovery. Here we develop a machine...
7.
Chongsaritsinsuk J, Steigmeyer A, Mahoney K, Rosenfeld M, Lucas T, Smith C, et al.
Nat Commun
. 2023 Oct;
14(1):6169.
PMID: 37794035
Mucin-domain glycoproteins are densely O-glycosylated and play critical roles in a host of biological functions. In particular, the T cell immunoglobulin and mucin-domain containing family of proteins (TIM-1, -3, -4)...
8.
Kim S, Kearns F, Rosenfeld M, Votapka L, Casalino L, Papanikolas M, et al.
Cell Rep Phys Sci
. 2023 Apr;
4(4):101346.
PMID: 37077408
Viral variants of concern continue to arise for SARS-CoV-2, potentially impacting both methods for detection and mechanisms of action. Here, we investigate the effect of an evolving spike positive charge...
9.
Moghadasi S, Heilmann E, Khalil A, Nnabuife C, Kearns F, Ye C, et al.
Sci Adv
. 2023 Mar;
9(13):eade8778.
PMID: 36989354
Vaccines and drugs have helped reduce disease severity and blunt the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, ongoing virus transmission, continuous evolution, and increasing selective pressures...
10.
Chongsaritsinsuk J, Steigmeyer A, Mahoney K, Rosenfeld M, Lucas T, Ince D, et al.
bioRxiv
. 2023 Feb;
PMID: 36778266
Mucin-domain glycoproteins are densely O-glycosylated and play critical roles in a host of biological functions. In particular, the T cell immunoglobulin and mucin-domain containing family of proteins (TIM-1, -3, -4)...