Fiona A Harding
Overview
Explore the profile of Fiona A Harding including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
393
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0
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Recent Articles
1.
Arias-Badia M, Chen P, Lwin Y, Srinath A, Lyu A, Fan Z, et al.
JCI Insight
. 2025 Feb;
PMID: 40014402
While immune checkpoint inhibition (CPI) has reshaped cancer treatment, the majority of cancer patients do not benefit from this approach, which can also cause immune-related adverse events. Induction of IFNγ...
2.
Tsao H, Anderson S, Finn K, Perera J, Pass L, Schneider E, et al.
Immunity
. 2024 Nov;
57(12):2863-2878.e12.
PMID: 39561763
The aminopeptidase, endoplasmic reticulum aminopeptidase 1 (ERAP1), trims peptides for loading into major histocompatibility complex class I (MHC class I), and loss of this activity has broad effects on the...
3.
Stickler M, Reddy A, Xiong J, Wong M, Akamatsu Y, Hinton P, et al.
Protein Eng Des Sel
. 2020 Jul;
32(12):543-554.
PMID: 32725169
Humanized and fully human sequence-derived therapeutic antibodies retain the capacity to induce anti-drug antibodies. Daclizumab (humanized version of the murine anti-Tac antibody; E.HAT) was selected for a proof of concept...
4.
Belmar N, Chan S, Fox M, Samayoa J, Stickler M, Tran N, et al.
J Immunol
. 2017 Apr;
198(11):4502-4512.
PMID: 28446565
Recent advances in immuno-oncology have shown that the immune system can be activated to induce long-term, durable antitumor responses. For immuno-oncology drug development, immune activation is often explored using rat...
5.
Harding F, Stickler M, Razo J, DuBridge R
MAbs
. 2010 Apr;
2(3):256-65.
PMID: 20400861
Monoclonal antibodies represent an attractive therapeutic tool as they are highly specific for their targets, convey effector functions and enjoy robust manufacturing procedures. Humanization of murine monoclonal antibodies has vastly...
6.
Harding F, Liu A, Stickler M, Razo O, Chin R, Faravashi N, et al.
Mol Cancer Ther
. 2005 Nov;
4(11):1791-800.
PMID: 16276001
Antibody-directed enzyme prodrug therapy (ADEPT) delivers chemotherapeutic agents in high concentration to tumor tissue while minimizing systemic drug exposure. beta-Lactamases are particularly useful enzymes for ADEPT systems due to their...
7.
Yeung V, Chang J, Miller J, Barnett C, Stickler M, Harding F
J Immunol
. 2004 May;
172(11):6658-65.
PMID: 15153481
The BALB/cByJ mouse strain displays an immunodominant T cell response directed at the same CD4(+) T cell epitope peptide region in human IFN-beta, as detected in a human population-based assay....
8.
Stickler M, Rochanayon N, Razo O, Mucha J, Gebel W, Faravashi N, et al.
Toxicol Sci
. 2003 Dec;
77(2):280-9.
PMID: 14691215
A method to rank proteins based on their relative immunogenicity has been devised. A statistical analysis of peptide-specific responses in large human donor pools provides a structure index value metric...
9.
Stickler M, Chin R, Faravashi N, Gebel W, Razo O, Rochanayon N, et al.
J Immunol Methods
. 2003 Oct;
281(1-2):95-108.
PMID: 14580884
A human cell-based method to identify functional CD4(+) T-cell epitopes in any protein has been developed. Proteins are tested as synthetic 15-mer peptides offset by three amino acids. Percent responses...
10.
Mucha J, Stickler M, Poulose A, Ganshaw G, Saldajeno M, Collier K, et al.
BMC Immunol
. 2002 Mar;
3:2.
PMID: 11869454
Background: T helper epitopes are necessary for the induction of high titers of antigen-specific IgG antibodies. We are interested in the epitope modification of intact proteins as a method to...