Fiachra Humphries
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Explore the profile of Fiachra Humphries including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
701
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Recent Articles
1.
Yang S, Humphries F
Trends Cell Biol
. 2024 Oct;
PMID: 39384444
Mitochondria are signaling hubs that produce immunomodulatory metabolites during the immune response. In addition, mitochondria also facilitate the recruitment and anchoring of immune signaling complexes during infection. Evolutionary conserved signaling...
2.
Tse-Kang S, Wani K, Peterson N, Page A, Humphries F, Pukkila-Worley R
Immunity
. 2024 Sep;
57(10):2280-2295.e6.
PMID: 39299238
Toll/interleukin-1/resistance (TIR)-domain proteins with enzymatic activity are essential for immunity in plants, animals, and bacteria. However, it is not known how these proteins function in pathogen sensing in animals. We...
3.
Stine L, Humphries F
Trends Immunol
. 2024 May;
45(6):403-405.
PMID: 38760304
Recent studies have identified Cys in gasdermin D (GSDMD) as a highly targeted regulatory module controlling pyroptosis. Using chemical biology and genetic models, Du, Healy et al. recently identified GSDMD...
4.
Chen Y, Humphries F, Li M, Kanneganti T, Ye D
Cell Chem Biol
. 2024 May;
31(5):830-832.
PMID: 38759615
The rise of immunotherapy and mRNA vaccines has underscored the power of modulating the immune system for a desired response. In this Voices piece, the Cell Chemical Biology editors ask...
5.
Yang Y, Wang Y, Wang Z, Yan H, Gong Y, Hu Y, et al.
Nat Cell Biol
. 2024 Feb;
26(3):450-463.
PMID: 38326554
Memory CD8 T cells play a crucial role in infection and cancer and mount rapid responses to repeat antigen exposure. Although memory cell transcriptional programmes have been previously identified, the...
6.
Chen Y, Lei X, Jiang Z, Humphries F, Parsi K, Mustone N, et al.
Proc Natl Acad Sci U S A
. 2023 Nov;
120(47):e2308355120.
PMID: 37963251
A detailed understanding of the innate immune mechanisms involved in restricting SARS-CoV-2 infection and how the virus disrupts these processes could reveal new strategies to boost antiviral mechanisms and develop...
7.
Humphries F
Trends Immunol
. 2023 Sep;
44(10):760-762.
PMID: 37718174
Recent studies have characterized ancient forms of cyclic GMP-AMP (cGAMP) synthase (cGAS)-like receptors (cGLRs) in bacterial and Drosophila immunity. Using bioinformatics and biochemical screening, Li et al. recently constructed and...
8.
Barasa L, Chaudhuri S, Zhou J, Jiang Z, Choudhary S, Green R, et al.
J Am Chem Soc
. 2023 Sep;
145(37):20273-20288.
PMID: 37695732
The cGMP-AMP Synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway plays a critical role in sensing dsDNA localized to the cytosol, resulting in the activation of a robust inflammatory response. While...
9.
Humphries F, Shmuel-Galia L, Jiang Z, Zhou J, Barasa L, Mondal S, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(33):e2305420120.
PMID: 37549268
Stimulator of interferon genes (STING) is an essential adaptor protein required for the inflammatory response to cytosolic DNA. dsDNA activates cGAS to generate cGAMP, which binds and activates STING triggering...
10.
Shmuel-Galia L, Humphries F, Vierbuchen T, Jiang Z, Santos N, Johnson J, et al.
Cell Metab
. 2023 Jul;
35(8):1441-1456.e9.
PMID: 37494932
This study reveals a previously uncharacterized mechanism to restrict intestinal inflammation via a regulatory RNA transcribed from a noncoding genomic locus. We identified a novel transcript of the lncRNA HOXA11os...