Felix Thoma
Overview
Explore the profile of Felix Thoma including associated specialties, affiliations and a list of published articles.
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10
Citations
124
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Recent Articles
1.
Roussou R, Metzler D, Padovani F, Thoma F, Schwarz R, Shraiman B, et al.
EMBO J
. 2024 Aug;
43(22):5340-5359.
PMID: 39103491
Mitochondrial DNA (mtDNA) is present in multiple copies within cells and is required for mitochondrial ATP generation. Even within individual cells, mtDNA copies can differ in their sequence, a state...
2.
Seel A, Padovani F, Mayer M, Finster A, Bureik D, Thoma F, et al.
Nat Struct Mol Biol
. 2023 Sep;
30(10):1549-1560.
PMID: 37679564
To maintain stable DNA concentrations, proliferating cells need to coordinate DNA replication with cell growth. For nuclear DNA, eukaryotic cells achieve this by coupling DNA replication to cell-cycle progression, ensuring...
3.
Schulze C, Hadrich M, Borger J, Ruhmann B, Doring M, Sieber V, et al.
Microb Biotechnol
. 2023 May;
17(1):e14277.
PMID: 37256270
Vibrio natriegens is an emerging host for biotechnology due to its high growth and substrate consumption rates. In industrial processes typically fed-batch processes are applied to obtain high space-time yields....
4.
Thoma F, Appel C, Russ D, Huber J, Werner F, Blombach B
Microb Biotechnol
. 2023 Mar;
16(5):1041-1053.
PMID: 36905370
Corynebacterium glutamicum experiences a transient iron limitation during growth in minimal medium, which can be compensated by the external supplementation of protocatechuic acid (PCA). Although C. glutamicum is genetically equipped...
5.
Bunk D, Moriasy J, Thoma F, Jakubke C, Osman C, Horl D
Bioinformatics
. 2022 Feb;
38(9):2667-2669.
PMID: 35179572
Summary: Here, we introduce YeastMate, a user-friendly deep learning-based application for automated detection and segmentation of Saccharomyces cerevisiae cells and their mating and budding events in microscopy images. We build...
6.
Thoma F, Schulze C, Gutierrez-Coto C, Hadrich M, Huber J, Gunkel C, et al.
Microb Biotechnol
. 2021 Nov;
15(6):1671-1684.
PMID: 34843164
The biotechnological production of succinate bears serious potential to fully replace existing petrochemical approaches in the future. In order to establish an economically viable bioprocess, obtaining high titre, yield and...
7.
Jakubke C, Roussou R, Maiser A, Schug C, Thoma F, Bunk D, et al.
Sci Adv
. 2021 Sep;
7(36):eabi8886.
PMID: 34516914
Mitochondrial genomes (mtDNA) encode essential subunits of the mitochondrial respiratory chain. Mutations in mtDNA can cause a shortage in cellular energy supply, which can lead to numerous mitochondrial diseases. How...
8.
Mei J, Bohland C, Geiger A, Baur I, Berner K, Heuer S, et al.
Radiat Oncol
. 2021 Aug;
16(1):159.
PMID: 34412654
Background: Invasiveness is a major factor contributing to metastasis of tumour cells. Given the broad variety and plasticity of invasion mechanisms, assessing potential metastasis-promoting effects of irradiation for specific mechanisms...
9.
Thoma F, Blombach B
Essays Biochem
. 2021 Apr;
65(2):381-392.
PMID: 33835156
Vibrio natriegens is emerging as a promising host for biotechnology which is basically due to the remarkable intrinsic properties such as the exceptionally high growth and substrate consumption rates. The...
10.
Thoma F, Somborn-Schulz A, Schlehuber D, Keuter V, Deerberg G
Front Plant Sci
. 2020 May;
11:497.
PMID: 32391040
In contrast to the primary metabolism, responsible for essential synthesis mechanisms and mass balance in plants, the secondary metabolism is not of particular importance for each cell but for the...