Felix Scheuplein
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Explore the profile of Felix Scheuplein including associated specialties, affiliations and a list of published articles.
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20
Citations
730
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Recent Articles
1.
Scheuplein F, Renner F, Campbell J, Campbell R, De Savi C, Eckmann J, et al.
Front Immunol
. 2024 Nov;
15:1411395.
PMID: 39502695
Introduction: The serine/threonine kinase 17B (STK17B) is involved in setting the threshold for T cell activation and its absence sensitizes T cells to suboptimal stimuli. Consequently, STK17B represents an attractive...
2.
Patel N, Guan P, Bahal D, Hashem T, Scheuplein F, Schaub R, et al.
Int J Mol Sci
. 2020 Jun;
21(12).
PMID: 32560408
Invariant natural killer T cells (iNKTs) directly kill tumor cells and trans-activate the anti-tumor functions of dendritic cells (DC), natural killer (NK) cells, and T and B cells. As such,...
3.
Lundblad L, Gulec N, Poynter M, DeVault V, Dienz O, Boyson J, et al.
Pulm Pharmacol Ther
. 2017 May;
45:80-89.
PMID: 28483562
iNKT cells and mast cells have both been implicated in the syndrome of allergic asthma through their activation-induced release of Th2 type cytokines and secretion of histamine and other mediators,...
4.
Scheuplein F, Lamont D, Poynter M, Boyson J, Serreze D, Lundblad L, et al.
PLoS One
. 2015 Oct;
10(10):e0140729.
PMID: 26474487
Invariant Natural Killer T (iNKT) cells are a T cell subset expressing an invariant T Cell Receptor (TCR) that recognizes glycolipid antigens rather than peptides. The cells have both innate-like...
5.
Scheuplein F, Thariath A, MacDonald S, Truneh A, Mashal R, Schaub R
PLoS One
. 2013 Oct;
8(9):e76692.
PMID: 24086759
Invariant Natural Killer T (iNKT) cells are a subset of T cells recognizing glycolipid antigens presented by CD1d. Human iNKT cells express a conserved T cell receptor (TCR)-α chain (Vα24-Jα18)...
6.
Bannas P, Scheuplein F, Well L, Hermans-Borgmeyer I, Haag F, Koch-Nolte F
Mol Immunol
. 2011 Jun;
48(15-16):1762-70.
PMID: 21641039
T cells constitutively express low amounts of a toxin-related ADP-ribosylating ecto-enzyme, ART2.2. In inflammatory settings, cells release NAD, the substrate for ART2.2. The ART2.2 catalyzed ADP-ribosylation of cell surface proteins...
7.
Chen Y, Scheuplein F, Driver J, Hewes A, Reifsnyder P, Leiter E, et al.
J Immunol
. 2011 Mar;
186(7):4278-84.
PMID: 21357538
Although P2rx7 has been proposed as a type 1 diabetes (T1D) susceptibility gene in NOD mice, its potential pathogenic role has not been directly determined. To test this possibility, we...
8.
Driver J, Scheuplein F, Chen Y, Grier A, Wilson S, Serreze D
Diabetes
. 2009 Nov;
59(2):423-32.
PMID: 19903740
Objective: In part, activation of invariant natural killer T (iNKT)-cells with the superagonist alpha-galactosylceramide (alpha-GalCer) inhibits the development of T-cell-mediated autoimmune type 1 diabetes in NOD mice by inducing the...
9.
Scheuplein F, Rissiek B, Driver J, Chen Y, Koch-Nolte F, Serreze D
J Autoimmun
. 2009 Oct;
34(2):145-54.
PMID: 19796917
The ectoenzyme ADP-ribosyltransferase 2.2 (ART2.2) can apoptotically delete various T-cell subsets. Depending on the involved apoptotic T-cell subset, enhanced ART2.2 activity could result in immunosuppression or autoimmunity. Diminished activity of...
10.
Wesolowski J, Alzogaray V, Reyelt J, Unger M, Juarez K, Urrutia M, et al.
Med Microbiol Immunol
. 2009 Jun;
198(3):157-74.
PMID: 19529959
Antibodies are important tools for experimental research and medical applications. Most antibodies are composed of two heavy and two light chains. Both chains contribute to the antigen-binding site which is...