Felix J B Bauerlein
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Explore the profile of Felix J B Bauerlein including associated specialties, affiliations and a list of published articles.
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14
Citations
666
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Recent Articles
1.
Zhao D, Bauerlein F, Saha I, Hartl F, Baumeister W, Wilfling F
Mol Cell
. 2024 May;
84(10):1980-1994.e8.
PMID: 38759629
Aggregation of proteins containing expanded polyglutamine (polyQ) repeats is the cytopathologic hallmark of a group of dominantly inherited neurodegenerative diseases, including Huntington's disease (HD). Huntingtin (Htt), the disease protein of...
2.
Jentoft I, Bauerlein F, Welp L, Cooper B, Petrovic A, So C, et al.
Cell
. 2023 Nov;
186(24):5308-5327.e25.
PMID: 37922900
Mammalian oocytes are filled with poorly understood structures called cytoplasmic lattices. First discovered in the 1960s and speculated to correspond to mammalian yolk, ribosomal arrays, or intermediate filaments, their function...
3.
Li H, Menegaux A, Schmitz-Koep B, Neubauer A, Bauerlein F, Shit S, et al.
Hum Brain Mapp
. 2021 Sep;
42(18):5862-5872.
PMID: 34520080
In the last two decades, neuroscience has produced intriguing evidence for a central role of the claustrum in mammalian forebrain structure and function. However, relatively few in vivo studies of...
4.
Bauerlein F, Baumeister W
J Mol Biol
. 2021 Aug;
433(20):167187.
PMID: 34384780
Traditionally, structural biologists approach the complexity of cellular proteomes in a reductionist manner. Proteomes are fractionated, their molecular components purified and studied one-by-one using the experimental methods for structure determination...
5.
Hedderich D, Menegaux A, Li H, Schmitz-Koep B, Stampfli P, Bauml J, et al.
Cereb Cortex
. 2021 Jun;
31(12):5549-5559.
PMID: 34171095
Several observations suggest an impact of prematurity on the claustrum. First, the claustrum's development appears to depend on transient subplate neurons of intra-uterine brain development, which are affected by prematurity....
6.
Trinkaus V, Riera-Tur I, Martinez-Sanchez A, Bauerlein F, Guo Q, Arzberger T, et al.
Nat Commun
. 2021 Apr;
12(1):2110.
PMID: 33854052
The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. α-Syn inclusions were long thought to consist mainly of α-Syn fibrils, but recent reports pointed to...
7.
Bauerlein F, Fernandez-Busnadiego R, Baumeister W
Trends Cell Biol
. 2020 Sep;
30(12):951-966.
PMID: 32981805
Neurodegenerative diseases affect the lives of millions of people across the world, being particularly prevalent in the aging population. Despite huge research efforts, conclusive insights into the disease mechanisms are...
8.
Menegaux A, Bauerlein F, Vania A, Napiorkowski N, Neitzel J, Ruiz-Rizzo A, et al.
Neuroimage
. 2019 Dec;
208:116440.
PMID: 31841682
Aging impacts both visual short-term memory (vSTM) capacity and thalamo-cortical connectivity. According to the Neural Theory of Visual Attention, vSTM depends on the structural connectivity between posterior thalamus and visual...
9.
Bauerlein F, Saha I, Mishra A, Kalemanov M, Martinez-Sanchez A, Klein R, et al.
Cell
. 2017 Sep;
171(1):179-187.e10.
PMID: 28890085
Expression of many disease-related aggregation-prone proteins results in cytotoxicity and the formation of large intracellular inclusion bodies. To gain insight into the role of inclusions in pathology and the in ...
10.
Fernandez J, Laugks U, Schaffer M, Bauerlein F, Khoshouei M, Baumeister W, et al.
Biophys J
. 2016 Jan;
110(4):850-9.
PMID: 26743046
Imaging of fully hydrated, vitrified biological samples by electron tomography yields structural information about cellular protein complexes in situ. Here we present a computational procedure that removes artifacts of three-dimensional...