Felipe Slebe
Overview
Explore the profile of Felipe Slebe including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
227
Followers
0
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Recent Articles
1.
Marhold M, Vaz Batista M, Blancas I, Morales C, Saura-Manich C, Saavedra C, et al.
Future Oncol
. 2025 Feb;
:1-9.
PMID: 40018758
NCT06048718 (clinicaltrials.gov); 2023 -506,702-39-00 (EudraCT number).
2.
Canellas-Socias A, Cortina C, Hernando-Momblona X, Palomo-Ponce S, Mulholland E, Turon G, et al.
Nature
. 2022 Nov;
611(7936):603-613.
PMID: 36352230
Around 30-40% of patients with colorectal cancer (CRC) undergoing curative resection of the primary tumour will develop metastases in the subsequent years. Therapies to prevent disease relapse remain an unmet...
3.
Alvarez-Varela A, Novellasdemunt L, Barriga F, Hernando-Momblona X, Canellas-Socias A, Cano-Crespo S, et al.
Nat Cancer
. 2022 Jun;
3(9):1052-1070.
PMID: 35773527
Colorectal cancer (CRC) patient-derived organoids predict responses to chemotherapy. Here we used them to investigate relapse after treatment. Patient-derived organoids expand from highly proliferative LGR5 tumor cells; however, we discovered...
4.
Morral C, Stanisavljevic J, Hernando-Momblona X, Mereu E, Alvarez-Varela A, Cortina C, et al.
Cell Stem Cell
. 2020 May;
26(6):845-861.e12.
PMID: 32396863
Colorectal cancers (CRCs) are composed of an amalgam of cells with distinct genotypes and phenotypes. Here, we reveal a previously unappreciated heterogeneity in the biosynthetic capacities of CRC cells. We...
5.
Testoni G, Duran J, Garcia-Rocha M, Vilaplana F, Serrano A, Sebastian D, et al.
Cell Metab
. 2017 Jul;
26(1):256-266.e4.
PMID: 28683291
Glycogenin is considered essential for glycogen synthesis, as it acts as a primer for the initiation of the polysaccharide chain. Against expectations, glycogenin-deficient mice (Gyg KO) accumulate high amounts of...
6.
FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth
Slebe F, Rojo F, Vinaixa M, Garcia-Rocha M, Testoni G, Guiu M, et al.
Nat Commun
. 2016 Apr;
7:11199.
PMID: 27045898
The mechanisms that allow breast cancer (BCa) cells to metabolically sustain rapid growth are poorly understood. Here we report that BCa cells are dependent on a mechanism to supply precursors...
7.
Maldonado R, Mancilla H, Villarroel-Espindola F, Slebe F, Slebe J, Mendez R, et al.
J Cell Biochem
. 2016 Mar;
117(11):2597-607.
PMID: 27017955
Sertoli cell metabolism actively maintains the nutritional needs of germ cells. It has been described that after glucose incorporation in Sertoli cells, less than 1% is converted to glycogen suggesting...
8.
Mir-Coll J, Duran J, Slebe F, Garcia-Rocha M, Gomis R, Gasa R, et al.
Diabetologia
. 2016 Jan;
59(5):1012-20.
PMID: 26825527
Aims/hypothesis: Glycogen accumulation occurs in beta cells of diabetic patients and has been proposed to partly mediate glucotoxicity-induced beta cell dysfunction. However, the role of glycogen metabolism in beta cell...
9.
Gatica R, Bertinat R, Silva P, Kairath P, Slebe F, Pardo F, et al.
Histochem Cell Biol
. 2014 Nov;
143(3):313-24.
PMID: 25371328
Diabetic nephropathy (DN) is a major complication of diabetic patients and the leading cause of end-stage renal disease. Glomerular dysfunction plays a critical role in DN, but deterioration of renal...