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Felicity R Williams

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Articles 12
Citations 108
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Recent Articles
1.
Freer A, Williams F, Durman S, Hayden J, Armstrong M, Trivedi P
JHEP Rep . 2024 Dec; 6(12):101210. PMID: 39640219
Background & Aims: Fatigue is a commonly reported symptom of primary biliary cholangitis (PBC). We conducted a single-arm, open-label clinical trial to assess the efficacy of a physiotherapist-led home-based exercise...
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Nicholson T, Dhaliwal A, Quinlan J, Allen S, Williams F, Hazeldine J, et al.
Exp Mol Med . 2024 Jul; 56(7):1667-1681. PMID: 39026032
Patients with chronic liver disease (CLD) often present with significant frailty, sarcopenia, and impaired immune function. However, the mechanisms driving the development of these age-related phenotypes are not fully understood....
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Williams F, Quinlan J, Freer A, Morrison B, Sitch A, Hockey F, et al.
Aliment Pharmacol Ther . 2024 Jan; 59(4):547-557. PMID: 38173029
Background: There remains a lack of consensus on how to assess functional exercise capacity and physical frailty in patients with advanced chronic liver disease (CLD) being assessed for liver transplantation...
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Quinlan J, Dhaliwal A, Williams F, Allen S, Choudhary S, Rowlands A, et al.
Exp Physiol . 2023 May; 108(8):1066-1079. PMID: 37166422
New Findings: What is the central question of this study? To what extent does musculoskeletal impairment occur (i.e., muscle mass, quality and function) in patients with end stage liver disease...
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Wells G, Spiers J, Williams F, Li W, Tavabie O, Brennan P
Clin Med (Lond) . 2023 Jan; 23(1):73-75. PMID: 36697015
The mortality and working years lost from liver cirrhosis present a significant challenge both in the UK and globally. The recent British Association for the Study of the Liver (BASL)...
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Allen S, Seabright A, Quinlan J, Dhaliwal A, Williams F, Fine N, et al.
Cells . 2022 Apr; 11(7). PMID: 35406665
Sarcopenia is a common complication affecting liver disease patients, yet the underlying mechanisms remain unclear. We aimed to elucidate the cellular mechanisms that drive sarcopenia progression using an in vitro...
8.
Dhaliwal A, Williams F, Quinlan J, Allen S, Greig C, Filer A, et al.
Skelet Muscle . 2021 Dec; 11(1):27. PMID: 34895316
Background: Several chronic inflammatory diseases co-exist with and accelerate sarcopenia (reduction in muscle strength, function and mass) and negatively impact on both morbidity and mortality. There is currently limited research...
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Marjot T, Ray D, Williams F, Tomlinson J, Armstrong M
Lancet Gastroenterol Hepatol . 2021 Jul; 6(10):850-863. PMID: 34273289
Sleep is a complex, highly regulated process essential for human health and wellbeing. Increasingly, sleep-wake disturbance has been implicated in the pathogenesis of chronic liver disease, particularly the development and...
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Williams F, Milliken D, Lai J, Armstrong M
Hepatol Commun . 2021 Jun; 5(6):923-937. PMID: 34141980
Frailty has emerged as a powerful predictor of clinical outcomes (e.g., decompensation, hospitalization, mortality) in patients with end-stage liver disease (ESLD). It is therefore of paramount importance that all patients...