Farkas Sarnyai
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Explore the profile of Farkas Sarnyai including associated specialties, affiliations and a list of published articles.
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11
Citations
63
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Recent Articles
1.
Tibori K, Zambo V, Orosz G, Szelenyi P, Sarnyai F, Tamasi V, et al.
Sci Rep
. 2024 Jan;
14(1):177.
PMID: 38167845
Overnutrition and genetic predisposition are major risk factors for various metabolic disorders. Stearoyl-CoA desaturase-1 (SCD1) plays a key role in these conditions by synthesizing unsaturated fatty acids (FAs), thereby promoting...
2.
Nemeth K, Toth B, Sarnyai F, Koncz A, Lenzinger D, Kereszturi E, et al.
Nutr Metab (Lond)
. 2023 Apr;
20(1):19.
PMID: 37004042
Background: High fat diet (HFD) increases the likelihood of dyslipidemia, which can be a serious risk factor for atherosclerosis, diabetes or hepatosteatosis. Although changes in different blood lipid levels were...
3.
Sarnyai F, Kereszturi E, Szirmai K, Matyasi J, Al-Hag J, Csizmadia T, et al.
Int J Mol Sci
. 2022 Jul;
23(13).
PMID: 35806300
Trans fatty acids (TFAs) are not synthesized in the human body but are generally ingested in substantial amounts. The widespread view that TFAs, particularly those of industrial origin, are unhealthy...
4.
Tibori K, Orosz G, Zambo V, Szelenyi P, Sarnyai F, Tamasi V, et al.
Int J Mol Sci
. 2022 Jun;
23(11).
PMID: 35682900
Disturbances in lipid metabolism related to excessive food intake and sedentary lifestyle are among major risk of various metabolic disorders. Stearoyl-CoA desaturase-1 (SCD1) has an essential role in these diseases,...
5.
Sarnyai F, Somogyi A, Gor-Nagy Z, Zambo V, Szelenyi P, Matyasi J, et al.
Int J Mol Sci
. 2020 Apr;
21(7).
PMID: 32283839
Dietary trans fatty acids (TFAs) have been implicated in serious health risks, yet little is known about their cellular effects and metabolism. We aim to undertake an in vitro comparison...
6.
Sarnyai F, Szekerczes T, Csala M, Sumegi B, Szarka A, Schaff Z, et al.
Pathol Oncol Res
. 2019 Nov;
26(3):1797-1803.
PMID: 31705481
Acetaminophen (APAP) induced hepatotoxicity involves activation of c-Jun amino-terminal kinase (JNK), mitochondrial damage and ER stress. BGP-15, a hydroximic acid derivative, has been reported to have hepatoprotective effects in APAP...
7.
Zambo V, Simon-Szabo L, Sarnyai F, Matyasi J, Gor-Nagy Z, Somogyi A, et al.
FEBS Lett
. 2019 Sep;
594(3):530-539.
PMID: 31557308
Elevated fatty acid (FA) levels contribute to severe metabolic diseases. Unbalanced oversupply of saturated FAs is particularly damaging, which renders stearoyl-CoA desaturase (SCD1) activity an important factor of resistance. A...
8.
Sarnyai F, Berinkeine Donko M, Matyasi J, Gor-Nagy Z, Marczi I, Simon-Szabo L, et al.
Food Chem Toxicol
. 2018 Dec;
124:324-335.
PMID: 30572061
High fatty acid (FA) levels are deleterious to pancreatic β-cells, largely due to the accumulation of biosynthetic lipid intermediates, such as ceramides and diglycerides, which induce ER stress and apoptosis....
9.
Szelenyi P, Somogyi A, Sarnyai F, Zambo V, Simon-Szabo L, Kereszturi E, et al.
Biofactors
. 2018 Nov;
45(2):236-243.
PMID: 30496642
Local activation of cortisol in hormone target tissues is a major determinant of glucocorticoid effect. Disorders in this peripheral cortisol metabolism play an important role in the development of metabolic...
10.
Zambo V, Toth M, Schlachter K, Szelenyi P, Sarnyai F, Lotz G, et al.
FEBS Lett
. 2016 Feb;
590(5):661-71.
PMID: 26878259
Acyl-CoA desaturation in the endoplasmic reticulum (ER) membrane depends on cytosolic NADH or NADPH, whereas NADPH in the ER lumen is utilized by prereceptor glucocorticoid production. It was assumed that...