Fabio M R Amaral
Overview
Explore the profile of Fabio M R Amaral including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
328
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Recent Articles
1.
Gurashi K, Wang Y, Amaral F, Spence K, Cant R, Yao C, et al.
Cell Rep Med
. 2025 Feb;
6(2):101933.
PMID: 39892394
Approximately 30% of patients with chronic myelomonocytic leukemia (CMML) undergo transformation to a chemo-refractory blastic phase (BP-CMML). Seeking novel therapeutic approaches, we profiled blast transcriptomes from 42 BP-CMMLs, observing extensive...
2.
Nicosia L, Spencer G, Brooks N, Amaral F, Basma N, Chadwick J, et al.
Cancer Cell
. 2023 Nov;
41(12):2136-2153.e13.
PMID: 37995682
CCS1477 (inobrodib) is a potent, selective EP300/CBP bromodomain inhibitor which induces cell-cycle arrest and differentiation in hematologic malignancy model systems. In myeloid leukemia cells, it promotes rapid eviction of EP300/CBP...
3.
Wang Y, Lin C, Gurashi K, Wingelhofer B, Amaral F, Yao C, et al.
Leukemia
. 2023 Nov;
37(12):2507-2511.
PMID: 37919605
No abstract available.
4.
Ginn L, Maltas J, Baker M, Chaturvedi A, Wilson L, Guilbert R, et al.
Proc Natl Acad Sci U S A
. 2023 Sep;
120(40):e2300489120.
PMID: 37748077
Lung cancer is the leading cause of cancer deaths. Its high mortality is associated with high metastatic potential. Here, we show that the RAC1-selective guanine nucleotide exchange factor T cell...
5.
Camera F, Romero-Camarero I, Revell B, Amaral F, Sinclair O, Simeoni F, et al.
iScience
. 2023 Aug;
26(8):107319.
PMID: 37539037
Iroquois transcription factor gene is highly expressed in 20-30% of acute myeloid leukemia (AML) and contributes to the pathognomonic differentiation block. Intron 8 sequences ∼220kB downstream of exhibit histone acetylation,...
6.
Pearson S, Blance R, Yan F, Hsieh Y, Geary B, Amaral F, et al.
PLoS One
. 2023 May;
18(5):e0286412.
PMID: 37253035
Myelofibrosis is a myeloproliferative neoplasm (MPN) which typically results in reduced length and quality of life due to systemic symptoms and blood count changes arising from fibrotic changes in the...
7.
Wang Y, Yao C, Lin C, Gurashi K, Amaral F, Bossenbroek H, et al.
Br J Haematol
. 2023 Feb;
201(2):302-307.
PMID: 36746431
Leukaemic stem cell (LSC) gene expression has recently been linked to prognosis in patients with acute myeloid leukaemia (17-gene LSC score, LSC-17) and myelodysplastic syndromes. Although chronic myelomonocytic leukaemia (CMML)...
8.
Wang Y, Lin C, Yao C, Amaral F, Yu S, Kao C, et al.
Blood Adv
. 2023 Jan;
7(11):2528-2533.
PMID: 36705979
No abstract available.
9.
Maiques-Diaz A, Nicosia L, Basma N, Romero-Camarero I, Camera F, Spencer G, et al.
Oncogene
. 2022 Sep;
41(44):4841-4854.
PMID: 36171271
Pharmacologic inhibition of LSD1 induces molecular and morphologic differentiation of blast cells in acute myeloid leukemia (AML) patients harboring MLL gene translocations. In addition to its demethylase activity, LSD1 has...
10.
Williams M, Basma N, Amaral F, Wiseman D, Somervaille T
BMC Cancer
. 2021 Oct;
21(1):1153.
PMID: 34711181
Background: Disease relapse remains common following treatment of acute myeloid leukemia (AML) and is due to chemoresistance of leukemia cells with disease repopulating potential. To date, attempts to define the...