Fabio L Fernandes-Rosa
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Explore the profile of Fabio L Fernandes-Rosa including associated specialties, affiliations and a list of published articles.
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24
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450
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Recent Articles
1.
Fedlaoui B, Cosentino T, Al Sayed Z, Alexandre Coelho R, Giscos-Douriez I, Faedda N, et al.
Hypertension
. 2025 Feb;
PMID: 39936308
Background: Primary aldosteronism is the most common form of secondary hypertension. The most frequent genetic cause of aldosterone-producing adenomas is somatic mutations in the potassium channel KCNJ5. They affect the...
2.
Wu X, Azizan E, Goodchild E, Garg S, Hagiyama M, Cabrera C, et al.
Nat Genet
. 2023 Jun;
55(6):1009-1021.
PMID: 37291193
Aldosterone-producing adenomas (APAs) are the commonest curable cause of hypertension. Most have gain-of-function somatic mutations of ion channels or transporters. Herein we report the discovery, replication and phenotype of mutations...
3.
Fernandes-Rosa F, Boulkroun S, Fedlaoui B, Hureaux M, Travers-Allard S, Drossart T, et al.
Kidney Int
. 2023 Jan;
103(3):485-500.
PMID: 36646167
Hypertension (HT) is a major cardiovascular risk factor that affects 10% to 40% of the general population in an age-dependent manner. Detection of secondary forms of HT is particularly important...
4.
Abdellatif A, Fernandes-Rosa F, Boulkroun S, Zennaro M
Front Endocrinol (Lausanne)
. 2022 Dec;
13:995228.
PMID: 36506065
Primary aldosteronism is the most common form of secondary arterial hypertension, due to excessive aldosterone production from the adrenal gland. Although somatic mutations have been identified in aldosterone producing adenoma,...
5.
Le Floch E, Cosentino T, Larsen C, Beuschlein F, Reincke M, Amar L, et al.
Nat Commun
. 2022 Sep;
13(1):5198.
PMID: 36057693
Primary aldosteronism affects up to 10% of hypertensive patients and is responsible for treatment resistance and increased cardiovascular risk. Here we perform a genome-wide association study in a discovery cohort...
6.
De Sousa K, Abdellatif A, Giscos-Douriez I, Meatchi T, Amar L, Fernandes-Rosa F, et al.
J Clin Endocrinol Metab
. 2021 Sep;
107(2):419-434.
PMID: 34570225
Context: Aldosterone-producing adenomas (APAs) are a common cause of primary aldosteronism (PA). Despite the discovery of somatic mutations in APA and the characterization of multiple factors regulating adrenal differentiation and...
7.
Zhou J, Azizan E, Cabrera C, Fernandes-Rosa F, Boulkroun S, Argentesi G, et al.
Nat Genet
. 2021 Aug;
53(9):1360-1372.
PMID: 34385710
Most aldosterone-producing adenomas (APAs) have gain-of-function somatic mutations of ion channels or transporters. However, their frequency in aldosterone-producing cell clusters of normal adrenal gland suggests a requirement for codriver mutations...
8.
Hacini I, De Sousa K, Boulkroun S, Meatchi T, Amar L, Zennaro M, et al.
Eur J Endocrinol
. 2021 Jul;
185(3):405-412.
PMID: 34232123
Objective: Primary aldosteronism (PA) is the most common form of secondary and curable hypertension. Different germline and somatic mutations are found in aldosterone-producing adenoma (APA) and familial forms of the...
9.
Zennaro M, Boulkroun S, Fernandes-Rosa F
Nat Rev Endocrinol
. 2020 Jul;
16(10):578-589.
PMID: 32724183
Early diagnosis and appropriate treatment of primary aldosteronism, the most frequent cause of secondary hypertension, are crucial to prevent deleterious cardiovascular outcomes. In the past decade, the discovery of genetic...
10.
Fernandes-Rosa F, Boulkroun S, Zennaro M
Trends Mol Med
. 2020 Jun;
26(9):819-832.
PMID: 32563556
Aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia are the main cause of primary aldosteronism (PA), the most frequent form of secondary hypertension. Mutations in ion channels and ATPases have been...