Fabin Dang
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Explore the profile of Fabin Dang including associated specialties, affiliations and a list of published articles.
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20
Citations
628
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Recent Articles
1.
Nie L, Fei C, Fan Y, Dang F, Zhao Z, Zhu T, et al.
Mol Cell
. 2024 Aug;
84(17):3336-3353.e7.
PMID: 39173637
NLRP3 inflammasome activation, essential for cytokine secretion and pyroptosis in response to diverse stimuli, is closely associated with various diseases. Upon stimulation, NLRP3 undergoes subcellular membrane trafficking and conformational rearrangements,...
2.
Ke S, Dang F, Wang L, Chen J, Naik M, Li W, et al.
Nat Commun
. 2024 Apr;
15(1):3220.
PMID: 38622115
Induced oncoproteins degradation provides an attractive anti-cancer modality. Activation of anaphase-promoting complex (APC/C) prevents cell-cycle entry by targeting crucial mitotic proteins for degradation. Phosphorylation of its co-activator CDH1 modulates the...
3.
Ma J, Ma B, Liu T, Wang Z, Ye Q, Peng Y, et al.
Nat Commun
. 2024 Feb;
15(1):1871.
PMID: 38424044
CDK4/6 inhibitors (CDK4/6i) show anticancer activity in certain human malignancies, such as breast cancer. However, their application to other tumor types and intrinsic resistance mechanisms are still unclear. Here, we...
4.
Dang F, Bai L, Dong J, Hu X, Wang J, Paulo J, et al.
Sci Transl Med
. 2023 Dec;
15(725):eadh7668.
PMID: 38055802
Targeting angiotensin-converting enzyme 2 (ACE2) represents a promising and effective approach to combat not only the COVID-19 pandemic but also potential future pandemics arising from coronaviruses that depend on ACE2...
5.
Zhang T, Xu D, Liu J, Wang M, Duan L, Liu M, et al.
Nat Cell Biol
. 2023 Jul;
25(7):950-962.
PMID: 37400498
The prolyl hydroxylation of hypoxia-inducible factor 1α (HIF-1α) mediated by the EGLN-pVHL pathway represents a classic signalling mechanism that mediates cellular adaptation under hypoxia. Here we identify RIPK1, a known...
6.
Zhang T, Xu D, Trefts E, Lv M, Inuzuka H, Song G, et al.
Science
. 2023 Jun;
380(6652):1372-1380.
PMID: 37384704
Adenosine monophosphate-activated protein kinase (AMPK) activity is stimulated to promote metabolic adaptation upon energy stress. However, sustained metabolic stress may cause cell death. The mechanisms by which AMPK dictates cell...
7.
Rezaeian A, Dang F, Wei W
Neoplasia
. 2023 May;
41:100904.
PMID: 37148656
Circadian clock orchestrates the intergenic biochemical, physiological and behavioral changes to form an approximate 24h oscillation through the transcription-translation feedback loop (TTFL). Mechanistically, a heterodimer of transcriptional activator formed by...
8.
Ke S, Dang F, Wang L, Chen J, Naik M, Thavamani A, et al.
Res Sq
. 2023 Jan;
PMID: 36711754
Cyclin-dependent kinases (CDKs) mediated phosphorylation inactivates the anaphase-promoting complex (APC/C), an E3 ubiquitin ligase that contains the co-activator CDH1, to promote G1/S transition. PIN1 is a phosphorylation-directed proline isomerase and...
9.
Dang F, Nie L, Zhou J, Shimizu K, Chu C, Wu Z, et al.
Nat Commun
. 2021 Sep;
12(1):5386.
PMID: 34508104
Although inhibitors targeting CDK4/6 kinases (CDK4/6i) have shown promising clinical prospect in treating ER+/HER2- breast cancers, acquired drug resistance is frequently observed and mechanistic knowledge is needed to harness their...
10.
Dang F, Jiang C, Zhang T, Inuzuka H, Wei W
J Genet Genomics
. 2021 Aug;
48(7):652-655.
PMID: 34366270
No abstract available.