F S Wyllie
Overview
Explore the profile of F S Wyllie including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
569
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Recent Articles
1.
Jones C, Kipling D, Morris M, Hepburn P, Skinner J, Bounacer A, et al.
Mol Cell Biol
. 2000 Jul;
20(15):5690-9.
PMID: 10891505
An initiating role for RAS oncogene mutation in several epithelial cancers is supported by its high incidence in early-stage tumors and its ability to induce proliferation in the corresponding normal...
2.
Wyllie F, Jones C, Skinner J, Haughton M, Wallis C, Wynford-Thomas D, et al.
Nat Genet
. 1999 Dec;
24(1):16-7.
PMID: 10615119
No abstract available.
3.
Bond J, Webley K, Wyllie F, Jones C, Craig A, Hupp T, et al.
Oncogene
. 1999 Jul;
18(25):3788-92.
PMID: 10391688
The tumour suppressor gene p53 plays a major role in the cellular response to DNA damage, mediating growth arrest and/or apoptosis. Phosphorylation of the protein occurs at numerous sites in...
4.
Wyllie F, Haughton M, ROWSON J, Wynford-Thomas D
Br J Cancer
. 1999 Mar;
79(7-8):1111-20.
PMID: 10098744
Differentiated thyroid carcinomas (in contrast to the rarer anaplastic form) are unusual among human cancers in displaying a remarkably low frequency of p53 mutation and appear to retain wild-type (wt)...
5.
Bond J, Haughton M, ROWSON J, Smith P, Gire V, Wynford-Thomas D, et al.
Mol Cell Biol
. 1999 Mar;
19(4):3103-14.
PMID: 10082577
The accumulation of genetic abnormalities in a developing tumor is driven, at least in part, by the need to overcome inherent restraints on the replicative life span of human cells,...
6.
Parry E, Ulucan H, Wyllie F, Wynford-Thomas D, Parry J
Chromosoma
. 1999 Jan;
107(6-7):491-7.
PMID: 9914382
Using fluorescence in situ hybridisation (FISH) we have analysed the segregational fidelity of all the human chromosomes during mitotic cell division. The losses and gains of chromosomes were analysed in...
7.
Jones C, Soley A, Skinner J, Gupta J, Haughton M, Wyllie F, et al.
Exp Cell Res
. 1998 May;
240(2):333-9.
PMID: 9597006
Prevention of telomere erosion through acquisition of telomerase activity is thought to be an essential mechanism in most human cancer cells for avoidance of cellular senescence and crisis. It has...
8.
Wynford-Thomas D, Jones C, Wyllie F
Biol Signals
. 1996 May;
5(3):139-53.
PMID: 8864059
This review develops the concept of p53 as a transcription factor mediating growth arrest or cell death in response to long-term (senescence-related) as well as acute (DNA damage) signals. Evidence...
9.
Wyllie F, Haughton M, Bond J, ROWSON J, Jones C, Wynford-Thomas D
Oncogene
. 1996 Mar;
12(5):1077-82.
PMID: 8649799
It is now likely that the cyclin-kinase inhibitor, p21(WAF1/SD11), is a key effector of p53-mediated cell-cycle arrest at the G(1)/S checkpoint following DNA damage. More recently, however, in vitro data...
10.
Jones C, Shaw J, Wyllie F, Gaillard N, Schlumberger M, Wynford-Thomas D
Mol Cell Endocrinol
. 1996 Jan;
116(1):115-9.
PMID: 8822272
p16INK4a (MTS1) is an important negative regulator of mammalian cell proliferation, acting via inhibition of CDK4/cyclin D-dependent phosphorylation of pRb to prevent progression through the G1 phase of the cell...