F Phil Brooks 3rd
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Explore the profile of F Phil Brooks 3rd including associated specialties, affiliations and a list of published articles.
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8
Citations
59
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Recent Articles
1.
Itkis D, Phil Brooks 3rd F, Brooks F, Davis H, Hotter R, Wong-Campos J, et al.
bioRxiv
. 2025 Mar;
PMID: 40060643
Bidirectional microscopy (BDM) combines simultaneous targeted optical perturbation and imaging of biophysical or biochemical signals (e.g. membrane voltage, Ca , or signaling molecules). A core challenge in BDM is precise...
2.
Phil Brooks 3rd F, Gong D, Davis H, Park P, Qi Y, Cohen A
Sci Adv
. 2025 Jan;
11(2):eadp5763.
PMID: 39772682
Microbial rhodopsin-derived genetically encoded voltage indicators (GEVIs) are powerful tools for mapping bioelectrical dynamics in cell culture and in live animals. Förster resonance energy transfer (FRET)-opsin GEVIs use voltage-dependent quenching...
3.
Phil Brooks 3rd F, Davis H, Wong-Campos J, Cohen A
Neurophotonics
. 2024 Aug;
11(3):035007.
PMID: 39139631
Significance: Genetically encoded voltage indicators (GEVIs) are a valuable tool for studying neural circuits , but the relative merits and limitations of one-photon (1P) versus two-photon (2P) voltage imaging are...
4.
Phil Brooks 3rd F, Davis H, Park P, Qi Y, Cohen A
bioRxiv
. 2024 Apr;
PMID: 38617370
Microbial rhodopsin-derived genetically encoded voltage indicators (GEVIs) are powerful tools for mapping bioelectrical dynamics in cell culture and in live animals. Förster resonance energy transfer (FRET)-opsin GEVIs use voltage-dependent changes...
5.
Phil Brooks 3rd F, Davis H, Wong-Campos J, Cohen A
bioRxiv
. 2023 Nov;
PMID: 38014011
Significance: Genetically encoded voltage indicators (GEVIs) are a valuable tool for studying neural circuits , but the relative merits and limitations of one-photon (1P) vs. two-photon (2P) voltage imaging are...
6.
Hayward R, Phil Brooks 3rd F, Yang S, Gao S, Cohen A
Elife
. 2023 Oct;
12.
PMID: 37801078
Many channelrhodopsins are permeable to protons. We found that in neurons, activation of a high-current channelrhodopsin, CheRiff, led to significant acidification, with faster acidification in the dendrites than in the...
7.
Hayward R, Phil Brooks 3rd F, Yang S, Gao S, Cohen A
bioRxiv
. 2023 Feb;
PMID: 36798192
Statement Of Significance: Acidification is an undesirable artifact of optogenetic stimulation. Low proton-permeability opsins minimize this artifact while still allowing robust optogenetic control.
8.
Chien M, Brinks D, Testa-Silva G, Tian H, Phil Brooks 3rd F, Adam Y, et al.
Sci Adv
. 2021 May;
7(19).
PMID: 33952514
Photoactivated genetically encoded voltage indicators (GEVIs) have the potential to enable optically sectioned voltage imaging at the intersection of a photoactivation beam and an imaging beam. We developed a pooled...
9.
Thomas W, Phil Brooks 3rd F, Burnim A, Bacik J, Stubbe J, Kaelber J, et al.
Nat Commun
. 2019 Jun;
10(1):2653.
PMID: 31201319
Ribonucleotide reductases (RNRs) use a conserved radical-based mechanism to catalyze the conversion of ribonucleotides to deoxyribonucleotides. Within the RNR family, class Ib RNRs are notable for being largely restricted to...