F J Staal
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Explore the profile of F J Staal including associated specialties, affiliations and a list of published articles.
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25
Citations
843
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Recent Articles
1.
Staal F, Clevers H
Hematol J
. 2002 Mar;
1(1):3-6.
PMID: 11920163
The founding members of the TCF family are T-cell factor-1 (Tcf-1) and lymphoid enhancing factor-1 (Lef-1). In adult mammals, Tcf-1 is uniquely expressed in T lymphocytes, while Lef-1 is expressed...
2.
Staal F, Weerkamp F, Langerak A, Hendriks R, Clevers H
Stem Cells
. 2001 May;
19(3):165-79.
PMID: 11359942
Initiation of gene transcription by transcription factors (TFs) is an important regulatory step in many developmental processes. The differentiation of T cell progenitors in the thymus is tightly controlled by...
3.
4.
Staal F, Meeldijk J, Moerer P, Jay P, van de Weerdt B, Vainio S, et al.
Eur J Immunol
. 2001 Mar;
31(1):285-93.
PMID: 11265645
T cell factor / lymphocyte enhancer factor (Tcf/Lef) transcription factors complex with the transcriptional co-activator beta-catenin to transduce Wnt signals in a variety of developmental systems. The prototypic family member...
5.
Ng Y, Veenhuizen P, Lokhorst H, Staal F
Cancer Gene Ther
. 2000 May;
7(4):624-8.
PMID: 10811481
A major goal in retroviral-based gene therapy is to establish methods that allow for the selection and tracking of transduced cell populations. Ex vivo gene marking of normal and malignant...
6.
Staal F, Burgering B, van de Wetering M, Clevers H
Int Immunol
. 1999 Apr;
11(3):317-23.
PMID: 10221643
Beta-catenin is the vertebrate homolog of the Drosophila segment polarity gene Armadillo and plays roles in both cell-cell adhesion and transduction of the Wnt signaling cascade. Recently, members of the...
7.
Staal F
Eur J Clin Invest
. 1998 May;
28(3):194-6.
PMID: 9568464
Glutathione is the main intracellular defence against oxidative stress and regulates the cellular redox potential. HIV infection is accompanied by severe metabolic and immune dysfunctions. Several laboratories have demonstrated that...
8.
Maurice M, Nakamura H, van der Voort E, Van Vliet A, Staal F, Tak P, et al.
J Immunol
. 1997 Feb;
158(3):1458-65.
PMID: 9013992
In rheumatoid arthritis (RA), T cells isolated from the synovial fluid (SF) show impaired responses to mitogenic stimulation compared with T cells from the peripheral blood (PB). Here it is...
9.
Staal F, Bakker A, Verkuijlen M, van Oort E, Spits H
Cancer Gene Ther
. 1996 Sep;
3(5):345-51.
PMID: 8894254
The coordinate expression of a marker gene and a therapeutic gene in one retroviral vector has considerable advantages. High-titer producer lines can potentially be selected on the basis of marker...
10.
Staal F, Res P, Weijer K, Spits H
Int Immunol
. 1995 Aug;
7(8):1301-9.
PMID: 7495737
Retroviral vectors have been used in most human gene therapy trials that have been undertaken. Many of these therapies have focused on the introduction of genes into hematopoietic stem cells...