F Cicchetti
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Explore the profile of F Cicchetti including associated specialties, affiliations and a list of published articles.
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53
Citations
952
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Recent Articles
1.
de Rus Jacquet A, Alpaugh M, Denis H, Tancredi J, Boutin M, Decaestecker J, et al.
Nat Commun
. 2023 Jun;
14(1):3651.
PMID: 37339976
Astrocyte dysfunction has previously been linked to multiple neurodegenerative disorders including Parkinson's disease (PD). Among their many roles, astrocytes are mediators of the brain immune response, and astrocyte reactivity is...
2.
Cicchetti F, David L, Siddu A, Denis H
Neurobiol Dis
. 2019 Jul;
130:104530.
PMID: 31301344
To date, medical and surgical interventions offered to patients with Parkinson's disease (PD) serve only to manage clinical symptoms; they have not shown the capacity to halt nor reverse degenerative...
3.
Alpaugh M, Cicchetti F
Neurobiol Dis
. 2019 Jun;
130:104504.
PMID: 31216439
Active and passive immunization have been used to treat human disease for hundreds of years and improvements in technology and knowledge is only increasing the number of therapeutic applications. The...
4.
LEpiscopo F, Drouin-Ouellet J, Tirolo C, Pulvirenti A, Giugno R, Testa N, et al.
Cell Death Dis
. 2016 Apr;
7:e2206.
PMID: 27124580
Glycogen synthase kinase-3β (GSK-3β) has emerged as a critical factor in several pathways involved in hippocampal neuronal maintenance and function. In Huntington's disease (HD), there are early hippocampal deficits both...
5.
Cisbani G, Drouin-Ouellet J, Gibrat C, Saint-Pierre M, Lagace M, Badrinarayanan S, et al.
Neurobiol Dis
. 2015 Aug;
82:430-444.
PMID: 26232588
The neuroprotective properties of cystamine identified in pre-clinical studies have fast-tracked this compound to clinical trials in Huntington's disease, showing tolerability and benefits on motor symptoms. We tested whether cystamine...
6.
Cisbani G, Cicchetti F
Neuropathol Appl Neurobiol
. 2013 Dec;
40(1):71-90.
PMID: 24304236
The hope that cell transplantation therapies will provide an ideal treatment option for neurodegenerative diseases has been considerably revived with the remarkable advancements in genetic engineering towards active cell fate...
7.
Cisbani G, Saint-Pierre M, Cicchetti F
Cell Transplant
. 2013 Jun;
23(10):1267-78.
PMID: 23768945
Cell replacement therapies have yielded variable and short-lived benefits in Huntington's disease (HD) patients. This suboptimal outcome is likely due to the fact that graft survival is compromised long term...
8.
Cisbani G, Cicchetti F
Cell Death Dis
. 2012 Aug;
3:e382.
PMID: 22932724
Huntington's disease (HD) is a devastating neurodegenerative disorder whose main hallmark is brain atrophy. However, several peripheral organs are considerably affected and their symptoms may, in fact, manifest before those...
9.
Drouin-Ouellet J, Lebel M, Filali M, Cicchetti F
Brain Behav Immun
. 2012 Mar;
26(6):880-5.
PMID: 22401992
The myeloid differentiation primary response gene 88 (MyD88) product is the most common adaptor protein implicated in Toll-like and interleukin receptor (TIR) domain signaling and thus plays an important role...
10.
Bousquet M, St-Amour I, Vandal M, Julien P, Cicchetti F, Calon F
Neurobiol Dis
. 2011 Oct;
45(1):529-38.
PMID: 21971528
The identification of modifiable nutritional risk factors is highly relevant to the development of preventive strategies for neurodegenerative disorders including Parkinson's disease (PD). In this study, adult C57BL/6 mice were...