Evgenia Megalou
Overview
Explore the profile of Evgenia Megalou including associated specialties, affiliations and a list of published articles.
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6
Citations
1158
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Recent Articles
1.
Dafnis I, Raftopoulou C, Mountaki C, Megalou E, Zannis V, Chroni A
Biochem J
. 2018 May;
475(10):1839-1859.
PMID: 29743204
The β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) initiates the production of amyloid-β peptide (Aβ), which is central to the pathogenesis of Alzheimer's disease (AD). Changes in brain cholesterol homeostasis...
2.
Schiavi A, Torgovnick A, Kell A, Megalou E, Castelein N, Guccini I, et al.
Exp Gerontol
. 2012 Dec;
48(2):191-201.
PMID: 23247094
Severe mitochondria deficiency leads to a number of devastating degenerative disorders, yet, mild mitochondrial dysfunction in different species, including the nematode Caenorhabditis elegans, can have pro-longevity effects. This apparent paradox...
3.
Marino G, Morselli E, Bennetzen M, Eisenberg T, Megalou E, Schroeder S, et al.
Autophagy
. 2011 Apr;
7(6):647-9.
PMID: 21460620
The acetylase inhibitor, spermidine and the deacetylase activator, resveratrol, both induce autophagy and prolong life span of the model organism Caenorhabditis elegans in an autophagydependent fashion. Based on these premises,...
4.
Morselli E, Marino G, Bennetzen M, Eisenberg T, Megalou E, Schroeder S, et al.
J Cell Biol
. 2011 Feb;
192(4):615-29.
PMID: 21339330
Autophagy protects organelles, cells, and organisms against several stress conditions. Induction of autophagy by resveratrol requires the nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 1 (SIRT1). In this paper, we show that...
5.
Morselli E, Maiuri M, Markaki M, Megalou E, Pasparaki A, Palikaras K, et al.
Autophagy
. 2009 Dec;
6(1):186-8.
PMID: 20023410
The life span of various model organisms can be extended by caloric restriction as well as by autophagy-inducing pharmacological agents. Life span-prolonging effects have also been observed in yeast cells,...
6.
Eisenberg T, Knauer H, Schauer A, Buttner S, Ruckenstuhl C, Carmona-Gutierrez D, et al.
Nat Cell Biol
. 2009 Oct;
11(11):1305-14.
PMID: 19801973
Ageing results from complex genetically and epigenetically programmed processes that are elicited in part by noxious or stressful events that cause programmed cell death. Here, we report that administration of...