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Evert van den Broek

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Citations 92
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Recent Articles
1.
Bos M, Meyer N, Wijma A, Khatib-Chahidi K, van den Broek E, Ho C, et al.
Pancreas . 2025 Jan; PMID: 39854689
Objectives: A significant proportion of patients undergoing surgery for pancreatic ductal adenocarcinoma (PDAC) are anemic at the time of resection. In these patients, blood transfusions are omitted due to their...
2.
Bogie R, le Clercq C, Voorham Q, Cordes M, Sie D, Rausch C, et al.
Br J Cancer . 2021 Dec; 126(6):865-873. PMID: 34912077
Background: Post-colonoscopy colorectal cancers (PCCRCs) pose challenges in clinical practice. PCCRCs occur due to a combination of procedural and biological causes. In a nested case-control study, we compared clinical and...
3.
Hoogstrate Y, Komor M, Bottcher R, van Riet J, van de Werken H, van Lieshout S, et al.
Gigascience . 2021 Dec; 10(12). PMID: 34891161
Background: Fusion genes are typically identified by RNA sequencing (RNA-seq) without elucidating the causal genomic breakpoints. However, non-poly(A)-enriched RNA-seq contains large proportions of intronic reads that also span genomic breakpoints....
4.
Vonk J, de Wit J, Voskuil F, Tang Y, Hooghiemstra W, Linssen M, et al.
J Nucl Med . 2021 Sep; 63(5):672-678. PMID: 34531264
In most oral cancer patients, surgical treatment includes resection of the primary tumor combined with excision of lymph nodes (LNs), either for staging or for treatment. All LNs harvested during...
5.
den Uil S, van den Broek E, Coupe V, Vellinga T, Delis-van Diemen P, Bril H, et al.
BMC Gastroenterol . 2019 Aug; 19(1):146. PMID: 31420015
Background: Microvessel density (MVD), as a derived marker for angiogenesis, has been associated with poor outcome in several types of cancer. This study aimed to evaluate the prognostic value of...
6.
van den Broek E, den Uil S, Coupe V, Delis-van Diemen P, Bolijn A, Bril H, et al.
Oncotarget . 2018 Jul; 9(50):29445-29452. PMID: 30034629
Background: Colorectal cancer (CRC) is caused by genetic aberrations. is commonly involved in somatic focal DNA copy number losses, in more than one-third of CRCs. In this study, we aimed...
7.
van den Broek E, van Lieshout S, Rausch C, Ylstra B, van de Wiel M, Meijer G, et al.
F1000Res . 2017 Jul; 5:2340. PMID: 28713543
Development of cancer is driven by somatic alterations, including numerical and structural chromosomal aberrations. Currently, several computational methods are available and are widely applied to detect numerical copy number aberrations...
8.
den Uil S, Coupe V, Linnekamp J, van den Broek E, Goos J, Delis-van Diemen P, et al.
Br J Cancer . 2016 Nov; 115(12):1565-1574. PMID: 27855440
Background: Colorectal cancer (CRC) is the third most common cancer worldwide. Accurately identifying stage II CRC patients at risk for recurrence is an unmet clinical need. KCNQ1 was previously identified...
9.
van den Broek E, Krijgsman O, Sie D, Tijssen M, Mongera S, van de Wiel M, et al.
Oncotarget . 2016 Oct; 7(45):73876-73887. PMID: 27729614
Tumor profiling of DNA alterations, i.e. gene point mutations, somatic copy number aberrations (CNAs) and structural variants (SVs), improves insight into the molecular pathology of cancer and clinical outcome. Here,...
10.
van den Broek E, Dijkstra M, Krijgsman O, Sie D, Haan J, Traets J, et al.
PLoS One . 2015 Sep; 10(9):e0138141. PMID: 26375816
Background: Cancer is caused by somatic DNA alterations such as gene point mutations, DNA copy number aberrations (CNA) and structural variants (SVs). Genome-wide analyses of SVs in large sample series...