Evan F Welch
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Explore the profile of Evan F Welch including associated specialties, affiliations and a list of published articles.
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7
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33
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Recent Articles
1.
Welch E, Rush K, Eastman K, Bandarian V, Blackburn N
Dalton Trans
. 2025 Feb;
PMID: 39981625
Bioactive peptides generally require post-translational processing to convert them to their fully active forms. Peptidylglycine monooxygenase (PHM) is a copper-dependent enzyme that catalyzes C-alpha hydroxylation of a glycine-extended pro-peptide, a...
2.
Rush K, Alwan K, Conner A, Welch E, Blackburn N
Inorg Chem
. 2024 Oct;
63(45):21519-21530.
PMID: 39472424
Metallochaperones are small proteins that shuttle essential metal ions such as Cu selectively to their cellular targets. CusF has unusual Cu(I) coordination, bound by two methionines, one histidine and a...
3.
Rush K, Eastman K, Welch E, Bandarian V, Blackburn N
J Am Chem Soc
. 2024 Feb;
146(8):5074-5080.
PMID: 38363651
Peptidylglycine monooxygenase is a copper-dependent enzyme that catalyzes C-alpha hydroxylation of glycine extended pro-peptides, a critical post-translational step in peptide hormone processing. The canonical mechanism posits that dioxygen binds at...
4.
Arias R, Welch E, Blackburn N
Protein Sci
. 2023 Mar;
32(4):e4615.
PMID: 36880254
Peptidylglycine monooxygenase (PHM) is essential for the biosynthesis of many neuroendocrine peptides via a copper-dependent hydroxylation of a glycine-extended pro-peptide. The "canonical" mechanism requires the transfer of two electrons from...
5.
Welch E, Rush K, Arias R, Blackburn N
Biochemistry
. 2022 Apr;
61(8):665-677.
PMID: 35380039
Peptidylglycine monooxygenase (PHM) is essential for the posttranslational amidation of neuroendocrine peptides. An important aspect of the PHM mechanism is the complete coupling of oxygen reduction to substrate hydroxylation, which...
6.
Welch E, Rush K, Arias R, Blackburn N
J Inorg Biochem
. 2022 Mar;
231:111780.
PMID: 35303611
An important question is whether consensus mechanisms for copper monooxygenase enzymes such as peptidylglycine monooxygenase (PHM) and dopamine β-monooxygenase (DBM) generated via computational and spectroscopic approaches account for important experimental...
7.
Alwan K, Welch E, Blackburn N
Biochemistry
. 2019 Oct;
58(44):4436-4446.
PMID: 31626532
The M centers of the mononuclear monooxygenases peptidylglycine monooxygenase (PHM) and dopamine β-monooxygenase bind and activate dioxygen en route to substrate hydroxylation. Recently, we reported the rational design of a...
8.
Alwan K, Welch E, Arias R, Gambill B, Blackburn N
Biochemistry
. 2019 Jun;
58(28):3097-3108.
PMID: 31243953
Mononuclear copper monooxygenases peptidylglycine monooxygenase (PHM) and dopamine β-monooxygenase (DBM) catalyze the hydroxylation of high energy C-H bonds utilizing a pair of chemically distinct copper sites (CuH and CuM) separated...