Eva Caroff
Overview
Explore the profile of Eva Caroff including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
51
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Recent Articles
1.
Meyer E, Croxford A, Gnerre C, Kulig P, Murphy M, Jacob E, et al.
J Med Chem
. 2024 May;
67(10):8077-8098.
PMID: 38727100
Migration of immune cells to sites of inflammation is a critical step in the body's response to infections but also during autoimmune flares. Chemokine receptors, members of the GPCR receptors,...
2.
Hubler F, Renneberg D, Siendt H, Stamm S, Hilpert K, Caroff E, et al.
J Med Chem
. 2024 Mar;
67(5):4100-4119.
PMID: 38482828
C5a is an anaphylatoxin protein produced by the cleavage of the complement system's component C5 protein. It signals through the G-protein-coupled receptor C5a receptor 1 (C5aR1) to induce the chemotaxis...
3.
Meyer E, Aanismaa P, Ertel E, Huhn E, Strasser D, Rey M, et al.
J Med Chem
. 2023 Mar;
66(6):4179-4196.
PMID: 36883854
The CXCR3 chemokine receptor is a G protein-coupled receptor mainly expressed on immune cells from the lymphoid lineage, including activated T cells. Binding of its inducible chemokine ligands CXCL9, CXCL10,...
4.
Pons V, Garcia C, Tidten-Luksch N, Mac Sweeney A, Caroff E, Gales C, et al.
Biochem Pharmacol
. 2022 Oct;
206:115291.
PMID: 36306820
Selatogrel is a potent inhibitor of adenosine diphosphate (ADP) binding to the P2Y12 receptor, preventing platelet activation. We have previously shown that the P2Y12 receptor constitutively activates Gi- and Go-protein-mediated...
5.
Caroff E, Meyer E, Aanismaa P, Froidevaux S, Keller M, Piali L
J Med Chem
. 2022 Aug;
65(17):11533-11549.
PMID: 35969159
The chemokine receptor CXCR3 allows the selective recruitment of innate and adaptive inflammatory immune cells into inflamed tissue. CXCR3 ligands are secreted after exposure to pro-inflammatory cytokines. Upon binding to...
6.
Meyer E, Aanismaa P, Froidevaux S, Keller M, Piali L, Caroff E
J Med Chem
. 2022 Aug;
65(17):11513-11532.
PMID: 35947786
The chemokine receptor CXCR3 is a seven-transmembrane G-protein-coupled receptor (GPCR) involved in various pathologies, in particular autoimmune diseases. It is activated by the three chemokine ligands CXCL9, CXCL10, and CXCL11...
7.
Crescence L, Darbousset R, Caroff E, Hubler F, Riederer M, Panicot-Dubois L, et al.
Thromb Res
. 2021 Feb;
200:133-140.
PMID: 33610885
Introduction: Selatogrel is a reversible antagonist of the P2Y12 receptor. In rat thrombosis/haemostasis models, selatogrel was associated with lower blood loss than clopidogrel or ticagrelor at equivalent anti-thrombotic effect. Material...
8.
Ufer M, Huynh C, Van Lier J, Caroff E, Fischer H, Dingemanse J
Xenobiotica
. 2019 Jul;
50(4):427-434.
PMID: 31322041
The P2Y12 receptor antagonist selatogrel which exhibits rapid inhibition of platelet aggregation following subcutaneous administration is in development for the treatment of acute myocardial infarction.This human ADME study was performed...
9.
Rey M, Kramberg M, Hess P, Morrison K, Ernst R, Haag F, et al.
Pharmacol Res Perspect
. 2017 Aug;
5(5).
PMID: 28805949
The P2Y receptor is a validated target for prevention of major adverse cardiovascular events in patients with acute coronary syndrome. The aim of this study was to compare two direct-acting,...
10.
Caroff E, Hubler F, Meyer E, Renneberg D, Gnerre C, Treiber A, et al.
J Med Chem
. 2015 Nov;
58(23):9133-53.
PMID: 26550844
Recent post hoc analyses of several clinical trials with P2Y12 antagonists showed the need for new molecules being fully efficacious as antiplatelet agents and having a reduced propensity to cause...