Eva-Maria Willing
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Explore the profile of Eva-Maria Willing including associated specialties, affiliations and a list of published articles.
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21
Citations
945
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Recent Articles
1.
Pfarr N, von Schwarzenberg K, Zocholl D, Merkelbach-Bruse S, Siemanowski J, Mayr E, et al.
JCO Precis Oncol
. 2024 Mar;
8:e2300348.
PMID: 38513168
Purpose: Poly(ADP-ribose) polymerase inhibitors (PARPi) have shown promising clinical results in the treatment of ovarian cancer. Analysis of biomarker subgroups consistently revealed higher benefits for patients with homologous recombination deficiency...
2.
Willing E, Vollbrecht C, Vossing C, Weist P, Schallenberg S, Herbst J, et al.
Cancers (Basel)
. 2023 Jul;
15(13).
PMID: 37444554
The worldwide approval of the combination maintenance therapy of olaparib and bevacizumab in advanced high-grade serous ovarian cancer requires complex molecular diagnostic assays that are sufficiently robust for the routine...
3.
Szymansky A, Kruetzfeldt L, Heukamp L, Hertwig F, Theissen J, Deubzer H, et al.
J Pers Med
. 2021 Aug;
11(8).
PMID: 34442335
For many years, the risk-based therapy stratification of children with neuroblastoma has relied on clinical and molecular covariates. In recent years, genome analysis has revealed further alterations defining risk, tumor...
4.
Schatz S, Falk M, Jori B, Ramdani H, Schmidt S, Willing E, et al.
Cancers (Basel)
. 2020 Jul;
12(6).
PMID: 32599951
In recent years, Non-small cell lung cancer (NSCLC) has evolved into a prime example for precision oncology with multiple FDA-approved "precision" drugs. For the majority of NSCLC lacking targetable genetic...
5.
Bernhardt N, Brassac J, Dong X, Willing E, Poskar C, Kilian B, et al.
Plant J
. 2019 Dec;
102(3):493-506.
PMID: 31821649
Many conflicting hypotheses regarding the relationships among crops and wild species closely related to wheat (the genera Aegilops, Amblyopyrum, and Triticum) have been postulated. The contribution of hybridization to the...
6.
Kiefer C, Willing E, Jiao W, Sun H, Piednoel M, Humann U, et al.
Nat Plants
. 2019 Jul;
5(8):846-855.
PMID: 31358959
Comparative genomics can unravel the genetic basis of species differences; however, successful reports on quantitative traits are still scarce. Here we present genome assemblies of 31 so-far unassembled Brassicaceae plant...
7.
Chopra D, Mapar M, Stephan L, Albani M, Deneer A, Coupland G, et al.
Proc Natl Acad Sci U S A
. 2019 May;
116(24):12078-12083.
PMID: 31123146
The genetic and molecular analysis of trichome development in has generated a detailed knowledge about the underlying regulatory genes and networks. However, how rapidly these mechanisms diverge during evolution is...
8.
de Francisco Amorim M, Willing E, Szabo E, Francisco-Mangilet A, Droste-Borel I, Macek B, et al.
Plant Cell
. 2018 Oct;
30(11):2838-2854.
PMID: 30309899
Introns are removed by the spliceosome, a large macromolecular complex composed of five ribonucleoprotein subcomplexes (U snRNPs). The U1 snRNP, which binds to 5' splice sites, plays an essential role...
9.
Jiao W, Accinelli G, Hartwig B, Kiefer C, Baker D, Severing E, et al.
Genome Res
. 2017 Feb;
27(5):778-786.
PMID: 28159771
Long-read sequencing can overcome the weaknesses of short reads in the assembly of eukaryotic genomes; however, at present additional scaffolding is needed to achieve chromosome-level assemblies. We generated Pacific Biosciences...
10.
UVR2 ensures transgenerational genome stability under simulated natural UV-B in Arabidopsis thaliana
Willing E, Piofczyk T, Albert A, Winkler J, Schneeberger K, Pecinka A
Nat Commun
. 2016 Dec;
7:13522.
PMID: 27905394
Ground levels of solar UV-B radiation induce DNA damage. Sessile phototrophic organisms such as vascular plants are recurrently exposed to sunlight and require UV-B photoreception, flavonols shielding, direct reversal of...