Eugenio Hardy
Overview
Explore the profile of Eugenio Hardy including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
354
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Recent Articles
1.
Fernandez-Patron C, Lopaschuk G, Hardy E
Nat Cardiovasc Res
. 2024 Aug;
3(6):627-636.
PMID: 39196226
Heart failure is a progressive syndrome with high morbidity and mortality rates. Here, we suggest that chronic exposure of the heart to risk factors for heart failure damages heart mitochondria,...
2.
Boggiano-Ayo T, Palacios-Oliva J, Lozada-Chang S, Relova-Hernandez E, Gomez-Perez J, Oliva G, et al.
Front Bioeng Biotechnol
. 2023 Dec;
11:1287551.
PMID: 38050488
We have developed a single process for producing two key COVID-19 vaccine antigens: SARS-CoV-2 receptor binding domain (RBD) monomer and dimer. These antigens are featured in various COVID-19 vaccine formats,...
3.
Hardy E, Sarker H, Fernandez-Patron C
Cells
. 2023 Jul;
12(13).
PMID: 37443732
We advance the notion that much like artificial nanoparticles, relatively more complex biological entities with nanometric dimensions such as pathogens (viruses, bacteria, and other microorganisms) may also acquire a biomolecular...
4.
Hardy E, Fernandez-Patron C
Cells
. 2022 Oct;
11(19).
PMID: 36230917
Endogenous glucocorticoids and their synthetic analogues, such as dexamethasone, stimulate receptor-mediated signal transduction mechanisms on target cells. Some of these mechanisms result in beneficial outcomes whereas others are deleterious in...
5.
Sarker H, Panigrahi R, Hardy E, Glover J, Elahi S, Fernandez-Patron C
Front Immunol
. 2022 Jul;
13:906687.
PMID: 35784352
Dexamethasone may reduce mortality in COVID-19 patients. Whether dexamethasone or endogenous glucocorticoids, such as cortisol, biochemically interact with SARS-CoV-2 spike 1 protein (S1), or its cellular receptor ACE2, is unknown....
6.
Fernandez-Patron C, Hardy E
Biomolecules
. 2022 May;
12(5).
PMID: 35625620
Much has been written about matrix metalloproteinases (MMPs) in health and disease conditions, but their roles in the setting of COVID-19 and associated illnesses remain understudied [...].
7.
Hardy E, Fernandez-Patron C
Biomolecules
. 2021 Apr;
11(3).
PMID: 33800947
Many individuals infected with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) develop no or only mild symptoms, but some can go on onto develop a spectrum of pathologies including pneumonia,...
8.
Sarker H, Hardy E, Haimour A, Karim M, Scholl-Burgi S, Martignetti J, et al.
Front Physiol
. 2020 Oct;
11:568718.
PMID: 33101055
Deficiency of matrix metalloproteinase 2 (MMP-2) causes a complex syndrome characterized by multicentric osteolysis, nodulosis, and arthropathy (MONA) as well as cardiac valve defects, dwarfism and hirsutism. MMP-2 deficient (...
9.
Hardy E, Fernandez-Patron C
Front Physiol
. 2020 Mar;
11:47.
PMID: 32116759
Bone is a dynamic organ that undergoes constant remodeling, an energetically costly process by which old bone is replaced and localized bone defects are repaired to renew the skeleton over...
10.
Sarker H, Hardy E, Haimour A, Maksymowych W, Botto L, Fernandez-Patron C
Sci Rep
. 2019 Mar;
9(1):4340.
PMID: 30867536
Non-genetic MMP-2 insufficiency is a relatively unexplored condition which could be induced by pathological overexpression of endogenous MMP-2 inhibitors such as TIMPs and/or the acute phase reactant alpha-2-macroglobulin. Here, we...