Eugene A Kapp
Overview
Explore the profile of Eugene A Kapp including associated specialties, affiliations and a list of published articles.
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40
Citations
1165
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Recent Articles
1.
Drulyte I, Ghai R, Ow S, Kapp E, Quek A, Panousis C, et al.
Structure
. 2024 Jul;
32(10):1705-1710.e3.
PMID: 39059382
Activated FXII (FXIIa) is the principal initiator of the plasma contact system and can activate both procoagulant and proinflammatory pathways. Its activity is important in the pathophysiology of hereditary angioedema...
2.
Ow S, Kapp E, Tomasetig V, Zalewski A, Simmonds J, Panousis C, et al.
MAbs
. 2023 Jan;
15(1):2163459.
PMID: 36628468
Hageman factor (FXII) is an essential component in the intrinsic coagulation cascade and a therapeutic target for the prophylactic treatment of hereditary angioedema (HAE). CSL312 (garadacimab) is a novel high-affinity...
3.
Gros M, Segura E, Rookhuizen D, Baudon B, Heurtebise-Chretien S, Burgdorf N, et al.
Cell Rep
. 2022 Aug;
40(7):111205.
PMID: 35977488
Despite its crucial role in initiation of cytotoxic immune responses, the molecular pathways underlying antigen cross-presentation remain incompletely understood. The mechanism of antigen exit from endocytic compartments into the cytosol...
4.
Cowan A, Smith N, Sandow J, Kapp E, Rustam Y, Murphy J, et al.
Nat Struct Mol Biol
. 2020 Sep;
27(11):1024-1031.
PMID: 32929280
BAK and BAX are essential mediators of apoptosis that oligomerize in response to death cues, thereby causing permeabilization of the mitochondrial outer membrane. Their transition from quiescent monomers to pore-forming...
5.
Mukherjee S, Fang M, Kok W, Kapp E, Thombare V, Huguet R, et al.
Anal Chem
. 2019 Sep;
91(19):12129-12133.
PMID: 31490671
Dityrosine cross-linking of Aβ peptides and α-synuclein is increasingly becoming recognized as a biomarker of neuropathological diseases. However, there remains a need for the development of analytical methods that enable...
6.
Binz P, Shofstahl J, Vizcaino J, Barsnes H, Chalkley R, Menschaert G, et al.
J Proteome Res
. 2019 May;
18(6):2686-2692.
PMID: 31081335
Mass-spectrometry-based proteomics enables the high-throughput identification and quantification of proteins, including sequence variants and post-translational modifications (PTMs) in biological samples. However, most workflows require that such variations be included in...
7.
Thomas O, Swearer S, Kapp E, Peng P, Tonkin-Hill G, Papenfuss A, et al.
FEBS J
. 2018 Dec;
286(1):66-81.
PMID: 30521091
The mechanisms that underpin the formation, growth and composition of otoliths, the biomineralized stones in the inner ear of fish, are largely unknown, as only a few fish inner ear...
8.
Coffey M, Dagley L, Seizova S, Kapp E, Infusini G, Roos D, et al.
mBio
. 2018 Nov;
9(5).
PMID: 30377279
infects approximately 30% of the world's population, causing disease primarily during pregnancy and in individuals with weakened immune systems. secretes and exports effector proteins that modulate the host during infection,...
9.
Greening D, Kapp E, Simpson R
Enzymes
. 2017 Oct;
42:27-64.
PMID: 29054270
Peptides play a seminal role in most physiological processes acting as neurotransmitters, hormones, antibiotics, and immune regulation. In the context of tumor biology, it is hypothesized that endogenous peptides, hormones,...
10.
Mukherjee S, Kapp E, Lothian A, Roberts A, Vasilev Y, Boughton B, et al.
Anal Chem
. 2017 Apr;
89(11):6136-6145.
PMID: 28453255
The use of mass spectrometry coupled with chemical cross-linking of proteins has become a powerful tool for proteins structure and interactions studies. Unlike structural analysis of proteins using chemical reagents...