Ethan C Alley
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Explore the profile of Ethan C Alley including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Crook O, Warmbrod K, Lipstein G, Chung C, Bakerlee C, McKelvey Jr T, et al.
Nat Commun
. 2022 Nov;
13(1):7374.
PMID: 36450726
The ability to identify the designer of engineered biological sequences-termed genetic engineering attribution (GEA)-would help ensure due credit for biotechnological innovation, while holding designers accountable to the communities they affect....
2.
Sandbrink J, Alley E, Watson M, Koblentz G, Esvelt K
Gene Ther
. 2022 Mar;
30(5):407-410.
PMID: 35264741
Optimizing viral vectors and their properties will be important for improving the effectiveness and safety of clinical gene therapy. However, such research may generate dual-use insights relevant to the enhancement...
3.
Biswas S, Khimulya G, Alley E, Esvelt K, Church G
Nat Methods
. 2021 Apr;
18(4):389-396.
PMID: 33828272
Protein engineering has enormous academic and industrial potential. However, it is limited by the lack of experimental assays that are consistent with the design goal and sufficiently high throughput to...
4.
Bradshaw W, Alley E, Huggins J, Lloyd A, Esvelt K
Nat Commun
. 2021 Jan;
12(1):232.
PMID: 33431829
Contact tracing is critical to controlling COVID-19, but most protocols only "forward-trace" to notify people who were recently exposed. Using a stochastic branching-process model, we find that "bidirectional" tracing to...
5.
Lewis G, Jordan J, Relman D, Koblentz G, Leung J, Dafoe A, et al.
Nat Commun
. 2020 Dec;
11(1):6294.
PMID: 33293537
Biology can be misused, and the risk of this causing widespread harm increases in step with the rapid march of technological progress. A key security challenge involves attribution: determining, in...
6.
Alley E, Turpin M, Liu A, Kulp-McDowall T, Swett J, Edison R, et al.
Nat Commun
. 2020 Dec;
11(1):6293.
PMID: 33293535
The promise of biotechnology is tempered by its potential for accidental or deliberate misuse. Reliably identifying telltale signatures characteristic to different genetic designers, termed 'genetic engineering attribution', would deter misuse,...
7.
Alley E, Khimulya G, Biswas S, AlQuraishi M, Church G
Nat Methods
. 2019 Oct;
16(12):1315-1322.
PMID: 31636460
Rational protein engineering requires a holistic understanding of protein function. Here, we apply deep learning to unlabeled amino-acid sequences to distill the fundamental features of a protein into a statistical...