Ervin Welker
Overview
Explore the profile of Ervin Welker including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
594
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Recent Articles
1.
Kulcsar P, Talas A, Ligeti Z, Toth E, Rakvacs Z, Bartos Z, et al.
Nat Commun
. 2023 Sep;
14(1):5746.
PMID: 37717069
Streptococcus pyogenes Cas9 (SpCas9) has been employed as a genome engineering tool with a promising potential within therapeutics. However, its off-target effects present major safety concerns for applications requiring high...
2.
Huszar K, Welker Z, Gyorgypal Z, Toth E, Ligeti Z, Kulcsar P, et al.
Nucleic Acids Res
. 2023 May;
51(11):5847-5863.
PMID: 37140059
Streptococcus pyogenes Cas9 (SpCas9) nuclease exhibits considerable position-dependent sequence preferences. The reason behind these preferences is not well understood and is difficult to rationalise, since the protein establishes interactions with...
3.
Kulcsar P, Talas A, Ligeti Z, Krausz S, Welker E
Nat Commun
. 2022 Nov;
13(1):6858.
PMID: 36369279
Several advancements have been made to SpCas9, the most widely used CRISPR/Cas genome editing tool, to reduce its unwanted off-target effects. The most promising approach is the development of increased-fidelity...
4.
Simon D, Talas A, Kulcsar P, Biczok Z, Krausz S, Varady G, et al.
Elife
. 2022 Feb;
11.
PMID: 35196219
Prime editing is a recently developed CRISPR/Cas9 based gene engineering tool that allows the introduction of short insertions, deletions, and substitutions into the genome. However, the efficiency of prime editing,...
5.
Teja Dondapati D, Cingaram P, Ayaydin F, Nyeste A, Kanyo A, Welker E, et al.
Membranes (Basel)
. 2021 Dec;
11(12).
PMID: 34940479
The cellular prion protein (PrP) is renowned for its infectious conformational isoform PrP, capable of templating subsequent conversions of healthy PrPs and thus triggering the group of incurable diseases known...
6.
Talas A, Simon D, Kulcsar P, Varga E, Krausz S, Welker E
Nat Commun
. 2021 Nov;
12(1):6353.
PMID: 34732717
Adenine and cytosine base editors (ABE, CBE) allow for precision genome engineering. Here, Base Editor Activity Reporter (BEAR), a plasmid-based fluorescent tool is introduced, which can be applied to report...
7.
Sangeetham S, Engelke A, Fodor E, Krausz S, Tatzelt J, Welker E
Sci Rep
. 2021 Feb;
11(1):3116.
PMID: 33542378
Scrapie prion, PrP, formation is the central event of all types of transmissible spongiform encephalopathies (TSEs), while the pathway with possible intermediates and their mechanism of formation from the normal...
8.
Talas A, Huszar K, Kulcsar P, Varga J, Varga E, Toth E, et al.
Nucleic Acids Res
. 2021 Jan;
49(6):e31.
PMID: 33450024
Detailed target-selectivity information and experiment-based efficacy prediction tools are primarily available for Streptococcus pyogenes Cas9 (SpCas9). One obstacle to develop such tools is the rarity of accurate data. Here, we...
9.
Kulcsar P, Talas A, Toth E, Nyeste A, Ligeti Z, Welker Z, et al.
Nat Commun
. 2020 Mar;
11(1):1223.
PMID: 32144253
Increased fidelity mutants of the SpCas9 nuclease constitute the most promising approach to mitigating its off-target effects. However, these variants are effective only in a restricted target space, and many...
10.
Toth E, Varga E, Kulcsar P, Kocsis-Jutka V, Krausz S, Nyeste A, et al.
Nucleic Acids Res
. 2020 Feb;
48(7):3722-3733.
PMID: 32107556
The widespread use of Cas12a (formerly Cpf1) nucleases for genome engineering is limited by their requirement for a rather long TTTV protospacer adjacent motif (PAM) sequence. Here we have aimed...