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Erno Brucher

Explore the profile of Erno Brucher including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 25
Citations 252
Followers 0
Related Specialties
Chemistry
Biochemistry
Top 10 Co-Authors
Zsolt Baranyai
Robert Kiraly
Imre Toth
Silvio Aime
Zoltan Kovacs
A Dean Sherry
Gyula Tircso
Alessandro Maiocchi
Istvan Banyai
Giovanni B Giovenzana
Published In
Inorg Chem
Chemistry
J Inorg Biochem
Dalton Trans
Front Chem
Affiliations
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Recent Articles
1.
Interaction of macrocyclic gadolinium-based MR contrast agents with Type I collagen. Equilibrium and kinetic studies
Guidolin N, Travagin F, Giovenzana G, Vagner A, Lotti S, Chianale F, et al.
Dalton Trans . 2020 Oct; 49(42):14863-14870. PMID: 33073806
The interactions of gadoterate meglumine, gadobutrol, gadoteridol and Gd(HB-DO3A) with bovine Type I collagen were investigated by ultrafiltration and dialysis. The affinity of the four agents to collagen is similar....
2.
Comparison of the equilibrium, kinetic and water exchange properties of some metal ion-DOTA and DOTA-bis(amide) complexes
Tircso G, Tircsone Benyo E, Garda Z, Singh J, Trokowski R, Brucher E, et al.
J Inorg Biochem . 2020 Mar; 206:111042. PMID: 32146160
The 1,7-diacetate-4,10-diacetamide substituted 1,4,7,10-tetraazacyclododecane structural unit is common to several responsive Magnetic Resonance Imaging (MRI) contrast agents (CAs). While some of these complexes (agents capable of sensing fluctuations in Zn,...
3.
Effect of the Nature of Donor Atoms on the Thermodynamic, Kinetic and Relaxation Properties of Mn(II) Complexes Formed With Some Trisubstituted 12-Membered Macrocyclic Ligands
Garda Z, Molnar E, Kalman F, Botar R, Nagy V, Baranyai Z, et al.
Front Chem . 2018 Aug; 6:232. PMID: 30151358
During the past few years increasing attention has been devoted to Mn(II) complexes as possible substitutes for Gd(III) complexes as contrast agents in MRI. Equilibrium (log or pMn value), kinetic...
4.
Equilibrium Thermodynamics, Formation, and Dissociation Kinetics of Trivalent Iron and Gallium Complexes of Triazacyclononane-Triphosphinate (TRAP) Chelators: Unraveling the Foundations of Highly Selective Ga-68 Labeling
Vagner A, Forgacs A, Brucher E, Toth I, Maiocchi A, Wurzer A, et al.
Front Chem . 2018 Jun; 6:170. PMID: 29876344
In order to rationalize the influence of Fe contamination on labeling with the Ga eluted from Ge/Ga-enerator, a detailed investigation was carried out on the equilibrium properties, formation and dissociation...
5.
Improved Efficacy of Synthesizing *M-Labeled DOTA Complexes in Binary Mixtures of Water and Organic Solvents. A Combined Radio- and Physicochemical Study
Perez-Malo M, Szabo G, Eppard E, Vagner A, Brucher E, Toth I, et al.
Inorg Chem . 2018 May; 57(10):6107-6117. PMID: 29746106
Typically, the synthesis of radiometal-based radiopharmaceuticals is performed in buffered aqueous solutions. We found that the presence of organic solvents like ethanol increased the radiolabeling yields of [Ga]Ga-DOTA (DOTA =...
6.
Exploiting the Proton Exchange as an Additional Route to Enhance the Relaxivity of Paramagnetic MRI Contrast Agents
Aime S, Baroni S, Castelli D, Brucher E, Fabian I, Colombo Serra S, et al.
Inorg Chem . 2018 Apr; 57(9):5567-5574. PMID: 29687717
The relaxivity of Gd(HP-DO3A) was studied as a function of pH and buffer composition in order to identify the main factors of the observed relaxation enhancement due to the exchange...
7.
Equilibrium, Kinetic and Structural Properties of Gallium(III) and Some Divalent Metal Complexes Formed with the New DATA and DATA Ligands
Farkas E, Nagel J, Waldron B, Parker D, Toth I, Brucher E, et al.
Chemistry . 2017 May; 23(43):10358-10371. PMID: 28504822
The development of Ge/ Ga generators has made the positron-emitting Ga isotope widely accessible and raised interest in new chelate complexes of Ga . The hexadentate 1,4-di(acetate)-6-methyl[amino(methyl)acetate]perhydro-1,4-diazepane (DATA ) ligand...
8.
The role of equilibrium and kinetic properties in the dissociation of Gd[DTPA-bis(methylamide)] (Omniscan) at near to physiological conditions
Baranyai Z, Brucher E, Uggeri F, Maiocchi A, Toth I, Andrasi M, et al.
Chemistry . 2015 Feb; 21(12):4789-99. PMID: 25678406
[Gd(DTPA-BMA)] is the principal constituent of Omniscan, a magnetic resonance imaging (MRI) contrast agent. In body fluids, endogenous ions (Zn(2+), Cu(2+), and Ca(2+)) may displace the Gd(3+). To assess the...
9.
Solution structures, stabilities, kinetics, and dynamics of DO3A and DO3A-sulphonamide complexes
Takacs A, Napolitano R, Purgel M, Benyei A, Zekany L, Brucher E, et al.
Inorg Chem . 2014 Feb; 53(6):2858-72. PMID: 24564285
The Gd(3+)-DO3A-arylsulphonamide (DO3A-SA) complex is a promising pH-sensitive MRI agent. The stability constants of the DO3A-SA and DO3A complexes formed with Mg(2+), Ca(2+), Mn(2+), Zn(2+), and Cu(2+) ions are similar,...
10.
Dissociation kinetics of open-chain and macrocyclic gadolinium(III)-aminopolycarboxylate complexes related to magnetic resonance imaging: catalytic effect of endogenous ligands
Baranyai Z, Palinkas Z, Uggeri F, Maiocchi A, Aime S, Brucher E
Chemistry . 2012 Nov; 18(51):16426-35. PMID: 23139193
The kinetics of the metal exchange reactions between open-chain Gd(DTPA)(2-) and Gd(DTPA-BMA), macrocyclic Gd(DOTA)(-) and Gd(HP-DO3A) complexes, and Cu(2+)  ions were investigated in the presence of endogenous citrate, phosphate, carbonate...