Erin M Schuman
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Explore the profile of Erin M Schuman including associated specialties, affiliations and a list of published articles.
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136
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10065
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Recent Articles
1.
van Oostrum M, Schuman E
Nat Rev Neurosci
. 2024 Dec;
26(2):65-81.
PMID: 39638892
Synapses are composed of thousands of proteins, providing the potential for extensive molecular diversity to shape synapse type-specific functional specializations. In this Review, we explore the landscape of synaptic diversity...
2.
van Oostrum M, Blok T, Giandomenico S, Tom Dieck S, Tushev G, Furst N, et al.
Cell
. 2023 Nov;
186(24):5411-5427.e23.
PMID: 37918396
Neurons build synaptic contacts using different protein combinations that define the specificity, function, and plasticity potential of synapses; however, the diversity of synaptic proteomes remains largely unexplored. We prepared synaptosomes...
3.
Bourke A, Spano T, Schuman E
Nat Neurosci
. 2023 Oct;
26(11):1842-1847.
PMID: 37872304
Despite an unprecedented number of women entering neuroscience, and decades-long recruitment and retention efforts, women continue to be disproportionately underrepresented in European academic tenure-track faculty and leadership positions. This Perspective...
4.
Schuhmacher J, Tom Dieck S, Christoforidis S, Landerer C, Davila Gallesio J, Hersemann L, et al.
Mol Cell
. 2023 Jun;
83(11):1839-1855.e13.
PMID: 37267905
Localized translation is vital to polarized cells and requires precise and robust distribution of different mRNAs and ribosomes across the cell. However, the underlying molecular mechanisms are poorly understood and...
5.
Sun C, Desch K, Nassim-Assir B, Giandomenico S, Nemcova P, Langer J, et al.
Science
. 2023 May;
380(6647):eadf2018.
PMID: 37228199
The proteasome, the major protein-degradation machine in cells, regulates neuronal synapses and long-term information storage. Here, using super-resolution microscopy, we found that the two essential subcomplexes of the proteasome, the...
6.
Giandomenico S, Schuman E
FEBS Open Bio
. 2023 Feb;
13(7):1164-1176.
PMID: 36815235
Gaining a mechanistic understanding of the molecular pathways underpinning cellular and organismal physiology invariably relies on the perturbation of an experimental system to infer causality. This can be achieved either...
7.
Bourke A, Schwarz A, Schuman E
Mol Cell
. 2023 Jan;
83(3):452-468.
PMID: 36669490
As our understanding of the cell interior has grown, we have come to appreciate that most cellular operations are localized, that is, they occur at discrete and identifiable locations or...
8.
Schroeder A, Pardi M, Keijser J, Dalmay T, Groisman A, Schuman E, et al.
Neuron
. 2023 Jan;
111(5):727-738.e8.
PMID: 36610397
Top-down projections convey a family of signals encoding previous experiences and current aims to the sensory neocortex, where they converge with external bottom-up information to enable perception and memory. Whereas...
9.
Verzelli P, Nold A, Sun C, Heilemann M, Schuman E, Tchumatchenko T
Sci Rep
. 2022 Dec;
12(1):22561.
PMID: 36581654
Single-molecule localization microscopy resolves objects below the diffraction limit of light via sparse, stochastic detection of target molecules. Single molecules appear as clustered detection events after image reconstruction. However, identification...
10.
Sun C, Schuman E
Mol Cell Neurosci
. 2022 Nov;
123:103793.
PMID: 36396040
Research in the past twenty years or so has revealed that neurons synthesize and degrade proteins at their synapses to enable synaptic proteome remodelling on demand and in real-time. Here...