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Erin C Macaulay

Explore the profile of Erin C Macaulay including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
11.
Lynch-Sutherland C, Chatterjee A, Stockwell P, Eccles M, Macaulay E
Front Oncol . 2020 May; 10:468. PMID: 32432029
Transposable elements (TEs) have an established role as important regulators of early human development, functioning as tissue-specific genes and regulatory elements. Functional TEs are highly active during early development, and...
12.
Reily-Bell A, Fisher A, Harrison B, Bowie S, Ray S, Hawkes M, et al.
Pathogens . 2020 Mar; 9(3). PMID: 32209998
Whether HPV is causative of pregnancy complications is uncertain. E6 and E7 affect functions underling preeclampsia (PET) in cultured trophoblasts, but whether E6 and E7 is produced in the placenta...
13.
Gamage T, Schierding W, Hurley D, Tsai P, Ludgate J, Bhoothpur C, et al.
Epigenetics . 2018 Nov; 13(12):1154-1173. PMID: 30475094
The placenta is a vital fetal exchange organ connecting mother and baby. Specialised placental epithelial cells, called trophoblasts, are essential for adequate placental function. Trophoblasts transform the maternal vasculature to...
14.
Gamage T, Schierding W, Tsai P, Ludgate J, Chamley L, Weeks R, et al.
Biol Open . 2018 Jul; 7(8). PMID: 30026266
The placenta is a fetal exchange organ connecting mother and baby that facilitates fetal growth DNA methylation is thought to impact placental development and function. Global DNA methylation studies using...
15.
Macaulay E, Chatterjee A, Cheng X, Baguley B, Eccles M, Morison I
Bioessays . 2017 Oct; 39(11). PMID: 28976008
The placenta invades the adjacent uterus and controls the maternal immune system, like a cancer invades surrounding organs and suppresses the local immune response. Intriguingly, placental and cancer cells are...
16.
Chatterjee A, Macaulay E, Ahn A, Ludgate J, Stockwell P, Weeks R, et al.
Epigenomics . 2017 May; 9(6):823-832. PMID: 28523967
Aim: Validation of sequencing-based DNA methylation data is an important step for meaningful translation of findings. However, there has been limited assessment of different platforms to validate methylation data from...
17.
Chatterjee A, Macaulay E, Rodger E, Stockwell P, Parry M, Roberts H, et al.
G3 (Bethesda) . 2016 May; 6(7):1911-21. PMID: 27172225
The human placenta is hypomethylated compared to somatic tissues. However, the degree and specificity of placental hypomethylation across the genome is unclear. We assessed genome-wide methylation of the human placenta...
18.
Macaulay E, Bloomfield F
Biol Reprod . 2016 Mar; 94(4):82. PMID: 26962116
No abstract available.
19.
Macaulay E, Roberts H, Cheng X, Jeffs A, Baguley B, Morison I
PLoS One . 2014 Apr; 9(4):e95840. PMID: 24759919
In the human placenta, DNA hypomethylation permits the expression of retrotransposon-derived genes that are normally silenced by methylation in somatic tissues. We previously identified hypomethylation of a retrotransposon-derived transcript of...
20.
Macaulay E, Weeks R, Andrews S, Morison I
Mamm Genome . 2011 Aug; 22(11-12):722-35. PMID: 21874386
DNA hypomethylation is assumed to be a feature of the mammalian placenta; however, its role in regulating placental gene expression is not well defined. In this study, MeDIP and Sequenom...